首页> 外文期刊>RSC Advances >Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells
【24h】

Versatile magnetic microdiscs for the radio enhancement and mechanical disruption of glioblastoma cancer cells

机译:用于无线电增强和胶质母细胞瘤癌细胞的机械破坏的多功能磁性Microdisc

获取原文
获取原文并翻译 | 示例
           

摘要

This study describes the use of highly versatile, lithographically defined magnetic microdiscs. Gold covered magnetic microdiscs are used in both radiosensitizing cancer cells, acting as intracellular emitters of secondary electrons during radiotherapy, and as well as inducing mechanical damage by exerting a mechanical torque when exposed to a rotating magnetic field. This study reveals that lithographically defined microdiscs with a uniform size of 2 microns in diameter highly increase the DNA damage and reduce the glioblastoma colony formation potential compared to conventional radiation therapy. Furthermore, the addition of mechanical disruption mediated by the magnetic component of the discs increased the efficiency of brain cancer cell killing.
机译:本研究描述了使用高通用的光刻定义的磁性Microdiss。 金覆盖的磁性Microdiscs用于放射腺度癌细胞,作为放射疗法期间的二次电子的细胞内发射器,以及在暴露于旋转磁场时施加机械扭矩诱导机械损坏。 该研究表明,与常规放射治疗相比,直径均匀尺寸为2微米的光谱定义的微芯片高度增加了DNA损伤,降低了胶质母细胞瘤菌落形成电位。 此外,通过盘的磁性成分介导的机械破坏增加了脑癌细胞杀伤的效率。

著录项

  • 来源
    《RSC Advances》 |2020年第14期|共11页
  • 作者单位

    Univ Cambridge Dept Phys JJ Thomson Ave Cambridge CB3 0HE England;

    Univ Cambridge Dept Phys JJ Thomson Ave Cambridge CB3 0HE England;

    Univ Cambridge Dept Oncol Hutchison MRC Res Ctr Cambridge Biomed Campus Cambridge CB2 0XZ England;

    Univ Manchester Fac Biol Med &

    Hlth Sch Med Sci Div Mol &

    Clin Canc Sci Manchester Lancs England;

    Univ Cambridge Dept Oncol Hutchison MRC Res Ctr Cambridge Biomed Campus Cambridge CB2 0XZ England;

    Univ Cambridge Dept Phys JJ Thomson Ave Cambridge CB3 0HE England;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号