A simple method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent

Gandioso Albert; El Fakiri Mohamed; Rovira Anna; Marchan Vicente

首页> 外文期刊>RSC Advances >A simple method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent

【24h】

A simple method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent

机译：通过使用BRCF2COOET作为二氟甲基化试剂合成对二氟甲基化吡啶和4-吡啶酮/喹诺酮的一种简单方法

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We describe a novel transition metal-free method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using readily available ethyl bromodifluoroacetate as a fluorine source. The formation ofN-difluoromethylated pyridines involves a two-step process in whichN-alkylation by ethyl bromodifluoroacetate is followed byin situhydrolysis of the ester and decarboxylation. Besides optimizing theN-difluoromethylation conditions and assessing the influence of steric and electronic effects on the outcome of the reaction, we have synthesized theN-difluoromethylated analogues of two fluorophores and demonstrated that their spectroscopic properties can be improved through replacement ofN-CH(3)group byN-CF2H.

机译：我们通过使用易于获得的溴二氟乙酸酯作为氟源来描述一种用于合成对二氟甲基化吡啶和4-吡啶酮/喹诺酮的一种新型过渡金属的方法。 NN-二氟甲基化吡啶的形成涉及通过乙基溴丙酸乙酯的α-烷基化的两步方法，然后是酯和脱羧的含水解。除了优化于二氟甲基化条件并评估空间和电子效应对反应结果的影响外，我们已经合成了两种荧光团的二氟甲基化类似物，并证明了它们的光谱性能可以通过替代N-CH（3）组来改善 BYN-CF2H。

著录项

来源
《RSC Advances》 |2020年第50期|共6页
作者
Gandioso Albert; El Fakiri Mohamed; Rovira Anna; Marchan Vicente;
展开▼
作者单位

Univ Barcelona IBUB Dept Quim Inorgan &

Organ Seccio Quim Organ Marti i Franques 1-11 E-08028 Barcelona Spain;

Univ Barcelona IBUB Dept Quim Inorgan &

Organ Seccio Quim Organ Marti i Franques 1-11 E-08028 Barcelona Spain;

Univ Barcelona IBUB Dept Quim Inorgan &

Organ Seccio Quim Organ Marti i Franques 1-11 E-08028 Barcelona Spain;

Univ Barcelona IBUB Dept Quim Inorgan &

Organ Seccio Quim Organ Marti i Franques 1-11 E-08028 Barcelona Spain;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. A simple method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent [J] . Gandioso Albert, El Fakiri Mohamed, Rovira Anna, RSC Advances . 2020,第50期

机译：通过使用BRCF2COOET作为二氟甲基化试剂合成对二氟甲基化吡啶和4-吡啶酮/喹诺酮的一种简单方法
2. Synthesis of substituted 4-pyridones and 4-aminopyridinium salts via a one-pot pyridine synthesis [J] . Hans Andersson, Sajal Das, Magnus Gustafsson Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2010,第32期

机译：通过一锅吡啶合成法合成取代的4-吡啶酮和4-氨基吡啶鎓盐
3. Simple,Selective,and Sensitive Spectrophotometric Method for Determination of Trace Amounts of Nickel(Ⅱ),Copper(Ⅱ), Cobalt(Ⅱ),and Iron(Ⅲ)with a Novel Reagent 2-Pyridine Carboxaldehyde Isonicotinyl Hydrazone [J] . Sajid H.Guzar, JIN Qin-han 高等学校化学研究（英文版） . 2008,第002期

机译：新型试剂2-吡啶羧甲醛异烟酰胺基Hy的简单，选择性，灵敏分光光度法测定痕量镍（Ⅱ），铜（Ⅱ），钴（Ⅱ）和铁（Ⅲ）
4. A Simple Method of Cyclization of the 2'-hydroxychaIcone with Polystyrene-Pyridine Resine under Mild Conditions [C] . Xuxu Zheng International Conference on Advanced Engineering Materials and Technology . 2011

机译：用聚苯乙烯 - 吡啶在温和条件下重新定位2'-羟基骨酮的简单方法
5. A simple and efficient synthesis of aromatic amides utilizing amino Grignard reagents. [D] . Muramulla, Savitha. 2005

机译：利用氨基格氏试剂可简单高效地合成芳香酰胺。
6. Three-Component One-Pot Approach to Highly Efficientand Sustainable Synthesis of the Functionalized Quinolones via Linear/BranchedDomino Protocols Key Synthetic Methods for the Floxacin of QuinoloneDrugs [O] . Hairui Bai, Fujun Liu, Xiaojing Wang, 2018

机译：三成分一锅法高效线性/支化的功能化喹诺酮类化合物的合成和可持续合成Domino协议喹诺酮氟沙星的关键合成方法毒品
7. A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent [O] . Albert Gandioso, Mohamed El Fakiri, Anna Rovira, 2020

机译：通过使用BRCF2COOET作为二氟甲基化试剂合成N-二氟甲基化吡啶和4-吡啶酮/喹诺酮的简单方法

A simple method for the synthesis ofN-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent

摘要

著录项

相似文献

相关主题

期刊订阅