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Study of Ra-223 uptake mechanism on hydroxyapatite and titanium dioxide nanoparticles as a function of pH

机译：基于pH的羟基磷灰石和二氧化钛纳米粒子的RA-223摄取机制研究

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摘要

The mechanism of Ra-223 uptake on hydroxyapatite and titanium dioxide nanoparticles was studied as a function of pH. Both materials are widely used in food industry and medicine. They offer properties suitable for labelling with medicinal radionuclides, particularly for targeted radionuclide therapy. The selected isotope, Ra-223, is an alpha emitter widely used in targeted alpha particle therapy due to high-dose delivery in very small tissue volume, nevertheless the results are applicable for any radium isotope including Ra-226. The study was performed in the pH range 4.5 to 12 for hydroxyapatite nanoparticles and 2 to 12 for titanium dioxide nanoparticles in Britton-Robinson buffer solution. Both nanomaterials at pH 6 and higher showed that over 95% of the radium has been sorbed. According to the applied chemical equilibrium model, the most important species playing a role in sorption on the edge-sites were RaCO3, RaPO4-, RaHPO4 and Ra(Ac-)(2), and Ra2+ and RaH2PO4+ on layer-sites. All experiments were conducted under free air conditions and no negative impact of CO2 was found. The surface complexation model was found suitable for describing radium uptake by the studied hydroxyapatite and titanium dioxide nanomaterials.
机译：研究了RA-223吸收对羟基磷灰石和二氧化钛纳米颗粒的机理作为pH的函数。两种材料广泛用于食品工业和医药。它们提供适合用药物放射性核素标记的性质，特别是针对靶向放射性核素治疗。所选择的同位素RA-223是由于在非常小的组织体积中的高剂量递送，α发射器是广泛用于靶向α颗粒疗法的α发射器，但结果适用于包括RA-226的任何镭同位素。该研究在4.5至12的pH范围4.5至12中进行羟基磷灰石纳米颗粒，2至12用于Britton-Robinson缓冲溶液中的二氧化钛纳米颗粒。 pH6和更高的纳米材料均显示出超过95％的镭苏氏菌。根据所应用的化学均衡模型，最重要的物种在边缘位点上的吸附作用是racO3，Rapo4-，Rahpo4和Ra（AC - ）（2），以及层位点上的Ra2 +和Rah2PO4 +。所有实验均在自由空气条件下进行，没有发现CO 2的负面影响。发现表面络合模型适用于描述研究的羟基磷灰石和二氧化钛纳米材料的镭吸收。

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  • 来源
    《RSC Advances》 |2020年第7期|共8页
  • 作者

    Suchankova Petra; Kukleva Ekaterina; Stamberg Karel; Nykl Pavel; Vlk Martin; Kozempel Jan;

  • 作者单位

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

    Czech Tech Univ Fac Nucl Sci &

    Phys Engn Dept Nucl Chem Brehova 7 Prague 11519 1 Czech Republic;

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  • 正文语种 eng
  • 中图分类 化学;
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