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首页> 外文期刊>RSC Advances >The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, andin vitrocytotoxic activities of novel parent and niosome nano-encapsulated Ho(iii) complexes
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The synthesis, characterization, DNA/BSA/HSA interactions, molecular modeling, antibacterial properties, andin vitrocytotoxic activities of novel parent and niosome nano-encapsulated Ho(iii) complexes

机译：新父母和定期纳米包封HO（III）复合物的合成，表征，DNA / BSA / HSA相互作用，分子建模，抗菌性能，挥霍细胞毒素活性

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Based on the importance of metal-centered complexes that can interact with DNA, this research focused on the synthesis of a new Ho(iii) complex. This complex was isolated and characterizedviaelemental analysis, and FT-IR, fluorescence, and UV-vis spectroscopy. Additional confirmation of the Ho(iii) complex structure was obtainedviasingle-crystal X-ray diffraction. DNA interaction studies were carried outviacircular dichroism (CD) spectroscopy, UV-vis absorption spectroscopy, viscosity measurements and emission spectroscopy; it was proposed that the metal complex acts as an effective DNA binder based on studies in the presence of fish DNA (FS-DNA), showing high binding affinity to DNA in the presence of hydrophobic and electron donating substituents. Also, the interactions of this complex with human (HSA) and bovine serum albumin (BSA) proteins were studiedviafluorescence spectroscopy techniques and the obtained results reveal an excellent propensity for binding in both cases. Furthermore, the interactions of the Ho(iii) complex with DNA, BSA and HSA were confirmedviamolecular docking analysis. The antimicrobial activities of the Ho(iii) complex were tested against Gram-negative bacteria and Gram-positive bacteria. In addition, a niosome nano-encapsulated Ho(iii) complex was synthesized, and the parent and encapsulated complexes were evaluated as potential antitumor candidates. The main structure of the Ho(iii) complex is maintained after encapsulation using niosome nanoparticles. The MTT method was used to assess the anticancer properties of the Ho(iii) complex and its encapsulated form toward human lung carcinoma and breast cancer cell lines. The anticancer activity in the encapsulated form was more than that of the parent Ho(iii) complex. In conclusion, these compounds could be considered as new antitumor candidates.
机译：基于对可与DNA相互作用金属中心的配合物的重要性，此研究集中在一个新何（III）络合物的合成。这种复杂的分离和分析characterizedviaelemental，和FT-IR，荧光和UV-vis光谱。何（III）络合物结构的附加的确认是obtainedviasingle晶体的X射线衍射。 DNA相互作用的研究分别进行outviacircular二色性（CD）光谱，紫外 - 可见吸收光谱，粘度测量和发射光谱;有人提议，该金属络合物作为基于在鱼DNA（FS-DNA）的存在下研究一种有效的DNA结合剂，显示出疏水性和供电子取代基的存在对DNA的高结合亲和力。此外，这种复杂的与人（HSA）和牛血清白蛋白（BSA）蛋白质的相互作用是studiedviafluorescence光谱技术和所获得的结果显示优异的倾向在这两种情况下的结合。此外，何（III）配合物与DNA，BSA和HSA的相互作用是confirmedviamolecular对接分析。何（III）络合物的抗微生物活性对革兰氏阴性菌和革兰氏阳性细菌进行测试。此外，类脂质体纳米包封何（ⅲ）配合物的合成，和亲和包封复合物评价为潜在的抗肿瘤候选者。何（III）络合物的主要结构使用类脂质体纳米颗粒封装之后被保持。采用MTT方法评估何（III）配合物和对人肺癌和乳腺癌细胞系中其包封形式的抗癌性质。在包封形式的抗癌活性大于父何（III）络合物。总之，这些化合物可被视为新的抗肿瘤候选。

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