• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Carotane sesquiterpenes fromFerula vesceritensis:in silicoanalysis as SARS-CoV-2 binding inhibitors
【24h】

Carotane sesquiterpenes fromFerula vesceritensis:in silicoanalysis as SARS-CoV-2 binding inhibitors

机译：Carotane Sesquitperpenes Flowferula Vesceritensis：硅杀硅酸分析为SARS-COV-2结合抑制剂

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Two sesquiterpenes, 8 alpha-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10 alpha-acetoxy-6 alpha-benzoate-jaeschkeanadiol (2) as well as, ten known analogues (3-10), and two sesquiterpene coumarins (11-12) were isolated from an organic root extract ofFerula vesceritensis(Fam. Apiaceae). Chemical structures were elucidated based on IR, 1D- and 2D-NMR and HRMS, spectroscopic analyses. With molecular overlap observed between two protease inhibitors that are being examined as anti-COVID-19 drugs, and sesquiterpenes isolated here, metabolite molecular docking calculations were made using the main protease (M-pro), which is required for viral multiplication as well as RNA-dependent RNA polymerase (RdRp).In silicobinding-inhibition analysis predicted that selectF. vesceritensissesquiterpenes can bind to these enzymes required for viral replication. Structures of the isolated constituents were also consistent with the chemo-systematic grouping ofF. vesceritensissecondary metabolites with otherFerulaspecies.
机译：两个均质萜烯，8α-anisate-dauc-4-eNE-3,9-二酮（韦醇溶解酸盐）（1）和10α-乙酰氧基-6α-苯甲酸酯 - jaeschkeanadiol（2）以及十个已知的类似物（3 -10），和两个倍半萜香豆素（11-12），从有机根提取物ofFerula vesceritensis（FAM。伞形科）分离。根据IR，1D-和2D-NMR及HRMS的化学结构进行了阐明，光谱分析。在将被检测为抗Covid-19药物的两个蛋白酶抑制剂之间观察到的分子重叠，并且使用倍二萜烯来使用主要蛋白酶（M-Pro）进行代谢物分子对接计算，这是病毒繁殖所需的RNA依赖性RNA聚合酶（RDRP）。硅纤维抑制抑制分析预测选择F. vesceritensesesquiterpenes可以与病毒复制所需的这些酶结合。分离成分的结构也与化学系统分组一致。 vesceritensissecondary代谢物与其他物质吸引人。

著录项

  • 来源
    《RSC Advances》 |2020年第57期|共8页
  • 作者

    Mohamed Tarik A.; Elshamy Abdelsamed I; Ibrahim Mahmoud A. A.; Zellagui Ammar; Moustafa Mahmoud F.; Abdelrahman Alaa H. M.; Ohta Shinji; Pare Paul W.; Hegazy Mohamed-Elamir F.;

  • 作者单位

    Natl Res Ctr Chem Med Plants Dept 33 El Bohouth St Giza 12622 Egypt;

    Natl Res Ctr Chem Nat Cpds Dept 33 El Bohouth St Giza 12622 Egypt;

    Menia Univ Fac Sci Chem Dept Computat Chem Lab Al Minya 61519 Egypt;

    Univ Larbi Ben Mhidi Fac Exact Sci &

    Life Sci &

    Nat Life Sci &

    Nat Dept Lab Biomol &

    Plant Breeding Oum El Bouaghi 4000 Algeria;

    King Khalid Univ Coll Sci Dept Biol Abha 9004 Saudi Arabia;

    Menia Univ Fac Sci Chem Dept Computat Chem Lab Al Minya 61519 Egypt;

    Hiroshima Univ Grad Sch Integrated Sci Life 1-7-1 Kagamiyama Higashihiroshima 7398521 Japan;

    Texas Tech Univ Dept Chem &

    Biochem Lubbock TX 79409 USA;

    Natl Res Ctr Chem Med Plants Dept 33 El Bohouth St Giza 12622 Egypt;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号