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Study on antibacterial properties and cytocompatibility of EPL coated 3D printed PCL/HA composite scaffolds

机译：EPL涂覆3D印刷PCL / HA复合支架抗菌性能及细胞栓塞性研究

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摘要

Biomaterial scaffolds play a critical role in bone tissue engineering. Moreover, 3D printing technology has enormous advantage in the manufacture of bioengineering scaffolds for patient-specific bone defect treatments. In order to provide an aseptic environment for bone regeneration, epsilon-poly-l-lysine (EPL), an antimicrobic cationic polypeptide, was used for surface modification of 3D printed polycaprolactone/hydroxyapatite (PCL/HA) scaffolds which were fabricated by fused deposition modeling (FDM) technology. The scaffold morphology and micro-structure were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and transform infrared spectroscopy (FT-IR). The release profile surface roughness, open porosity, and mechanical properties of the scaffolds were evaluated. Cell adhesion, proliferation, differentiation potential and antibacterial properties were also examined. As a result, 3D printed PCL/HA scaffolds with interconnected pores showed a slightly rough surface and improved mechanical properties due to adding hydroxyapatite (HA) particles. After being modified by EPL, favorable biocompatibility and osteoconductivity of epsilon-poly-l-lysine/polycaprolactone/hydroxyapatite (EPL/PCL/HA) scaffolds were observed. Moreover, antibacterial activity of the EPL/PCL/HA scaffolds was apparent. As a consequence, the EPL/PCL/HA scaffolds had great potential for bone regeneration and prevention of infections. This would yield a patient-specific bioactive and antibacterial composite scaffold for advanced bone tissue engineering applications.
机译：生物材料脚手架在骨组织工程中发挥着关键作用。此外，3D印刷技术在制造生物工程支架上具有巨大的优势，用于患者特异性骨缺损处理。为了提供用于骨再生的无菌环境，ε-聚-1-赖氨酸（EPL），抗菌阳离子多肽，用于3D印刷聚己内酯/羟基磷灰石（PCL / HA）支架的表面改性，其通过熔融沉积制造建模（FDM）技术。通过扫描电子显微镜（SEM），X射线衍射（XRD）和变换红外光谱（FT-IR），表征了支架形态和微结构。评估释放型材表面粗糙度，开放孔隙率和支架的机械性能。还检查了细胞粘附，增殖，分化电位和抗菌性质。结果，由于添加羟基磷灰石（HA）颗粒，具有相互连接的孔的3D印刷的PCL / HA支架显示出略微粗糙的表面和改善的机械性能。在通过EPL改性后，观察到ε-聚-L-赖氨酸/聚己内酯/羟基磷灰石（EPL / PCL / HA）支架的有利的生物相容性和骨导电性。此外，EPL / PCL / HA支架的抗菌活性是显而易见的。因此，EPL / PCL / HA支架具有很大的骨再生和预防感染的潜力。这将产生患者特异性的生物活性和抗菌复合支架，用于晚期骨组织工程应用。

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  • 来源
    《RSC Advances》 |2020年第8期|共12页
  • 作者

    Tian Lijiao; Zhang Zhenting; Tian Bin; Zhang Xin; Wang Na;

  • 作者单位

    Capital Med Univ Beijing Stomatol Hosp Sch Stomatol Beijing 100010 Peoples R China;

    Capital Med Univ Beijing Stomatol Hosp Sch Stomatol Beijing 100010 Peoples R China;

    Capital Med Univ Beijing Stomatol Hosp Sch Stomatol Beijing 100010 Peoples R China;

    Liangxiang Hosp Beijing Fangshan Dist Beijing 100010 Peoples R China;

    Capital Med Univ Beijing Stomatol Hosp Sch Stomatol Beijing 100010 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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