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Reaction-diffusion model as framework for understanding the role of riboflavin in 'eye defence' formulations

机译:反应扩散模型作为了解核黄素在“眼防御”制剂中的作用的框架

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摘要

Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, C-t, such that for riboflavin concentration > C-t the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.
机译:对基于商业核黄素的滴眼进行的UV可见光光谱分析表明,吸光度是维生素浓度的饱和功能。 这意味着阈值浓度,C-T,使得对于核黄素浓度> C-T的吸光度保持恒定,滴眼液的有效性与所用的剂量无关。 将这些实验结果与扩散反应模型相结合,以阐明角膜内的作用机制。 该模型预测眼液对UVB和UVC的有效性低,而它们对UVA具有良好的性能。 实际上,在角膜的中心,透射率明显减少,1小时后,与缺点的角膜相比,减少了约70%。

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  • 来源
    《RSC Advances》 |2020年第25期|共7页
  • 作者单位

    Univ Molise Consorzio Sviluppo Sistemi Grande Interfase CSGI Dept Med &

    Hlth Sci V Tiberio I-86100 Campobasso Italy;

    Pellegrini Hosp Corneal Transplant Ctr Naples Italy;

    Univ Molise Consorzio Sviluppo Sistemi Grande Interfase CSGI Dept Med &

    Hlth Sci V Tiberio I-86100 Campobasso Italy;

    Univ Molise Consorzio Sviluppo Sistemi Grande Interfase CSGI Dept Med &

    Hlth Sci V Tiberio I-86100 Campobasso Italy;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

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