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首页> 外文期刊>RSC Advances >Simulated spatial radiation impacts learning and memory ability with alterations of neuromorphology and gut microbiota in mice
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Simulated spatial radiation impacts learning and memory ability with alterations of neuromorphology and gut microbiota in mice

机译：模拟空间辐射对小鼠神经形态和肠道微生物改变的影响和记忆能力

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摘要

Complex space environments, including microgravity and radiation, affect the body's central nervous system, endocrine system, circulatory system, and reproductive system. Radiation-induced aberration in the neuronal integrity and cognitive functions are particularly well known. Moreover, ionizing radiation is a likely contributor to alterations in the microbiome. However, there is a lacuna between radiation-induced memory impairment and gut microbiota. The present study was aimed at investigating the effects of simulated space-type radiation on learning and memory ability and gut microbiota in mice. Adult mice were irradiated by Co-60-gamma rays at 4 Gy to simulate spatial radiation; behavioral experiments, pathological experiments, and transmission electron microscopy all showed that radiation impaired learning and memory ability and hippocampal neurons in mice, which was similar to the cognitive impairment in neurodegenerative diseases. In addition, we observed that radiation destroyed the colonic structure of mice, decreased the expression of tight junction proteins, and increased inflammation levels, which might lead to dysregulation of the intestinal microbiota. We found a correlation between the brain and colon in the changes in neurotransmitters associated with learning and memory. The 16S rRNA results showed that the bacteria associated with these neurotransmitters were also changed at the genus level and were significantly correlated. These results indicate that radiation-induced memory and cognitive impairment can be linked to gut microbiota through neurotransmitters.
机译：复杂的空间环境，包括微匍匐和辐射，影响身体的中枢神经系统，内分泌系统，循环系统和生殖系统。神经元完整性和认知函数中的辐射诱导的像差特别是众所周知的。此外，电离辐射是微生物组中的改变的可能结果。然而，辐射诱导的记忆损伤和肠道微生物之间存在平面图。本研究旨在研究模拟空间辐射对小鼠学习和记忆能力和肠道微生物的影响。通过Co-60-γ射线照射成人小鼠，以模拟空间辐射;行为实验，病理实验和透射电子显微镜都显示出辐射损害的小鼠中的学习和记忆能力和海马神经元，类似于神经变性疾病中的认知障碍。此外，我们观察到辐射破坏了小鼠的结肠结构，降低了紧密结蛋白的表达，增加了炎症水平，这可能导致肠道微生物瘤的失调。我们在与学习和记忆相关联的神经递质的变化中发现了大脑和结肠之间的相关性。 16S rRNA结果表明，与这些神经递质相关的细菌也在属级别发生变化，并且显着相关。这些结果表明，辐射诱导的记忆和认知障碍可以通过神经递质与肠道微生物植物连接。

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  • 来源
    《RSC Advances》 |2020年第27期|共13页
  • 作者

    Song Chen; Gao Xin; Song Wei; Zeng Deyong; Shan Shan; Yin Yishu; Li Yongzhi; Baranenko Denis; Lu Weihong;

  • 作者单位

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    Northwest Univ Coll Food Sci &

    Technol Xian 710069 Peoples R China;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

    ITMO Univ Biotechnol Millennium 3 St Petersburg Russia;

    Harbin Inst Technol Inst Extreme Environm Nutr &

    Protect Harbin Peoples R China;

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