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Effects of spermine on liver barrier function, amino acid transporters, immune status, and apoptosis in piglets

机译：精美对肝脏屏障功能，氨基酸转运蛋白，免疫状态和仔猪凋亡的影响

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摘要

This study investigated the effects of spermine supplementation and its extended duration on amino acid transporters, immune status, barrier function, and apoptosis in the liver. Eighty piglets were randomly assigned to a group receiving either a diet supplemented with spermine (0.4 mmol kg(-1) of body weight) or a restricted nutrient intake supplemented with saline in pairs for 7 h, 3 days, 6 days, and 9 days. Regardless of treatment time, spermine increased the levels of amino acid transporters, immunoglobulin M, antimicrobial peptides, cellular immune components, anti-inflammatory cytokines, mammalian target of rapamycin, ribosomal protein S6 kinase 1, signal transducer and activator of transcription 2 and 3, Janus kinase 2, zonula occludens 1 and 2, occluding, claudin-1, claudin-2, claudin-16 and Bcl-2 mRNA levels, whereas it decreased the levels of pro-inflammatory cytokines, inducible nitric oxide synthase, nuclear factor-kappa B P65, eukaryotic IF4E-binding protein 1, myosin light chain kinase, Bax, and caspase-3 mRNA in the liver (P < 0.05). These effects were also found in cases of prolonged spermine intake (P < 0.05). Spermine can decrease pro-inflammatory cytokines and caspase-3 levels. In conclusion, spermine may promote barrier function and improve amino acid transport, and can increase immune status and inhibit apoptosis in the liver.
机译：本研究研究了精美补充的影响及其延长持续时间对肝脏中氨基酸转运蛋白，免疫状态，屏障功能和细胞凋亡。将八十只仔猪随机分配给接受补充有精胺的饮食（0.4mmol kg（-1）体重）的饮食或含有盐水的限制营养摄入量，成对7小时，3天，6天和9天。 。无论治疗时间如何，精子增加了氨基酸转运蛋白水平，免疫球蛋白M，抗菌肽，细胞免疫组分，抗炎细胞因子，哺乳动物毒素，核糖瘤蛋白S6激酶1，信号传感器和转录2和3的活化剂， Janus激酶2，Zonula occludens 1和2，闭塞，克劳蛋白-1，Claudin-2，Claudin-16和Bcl-2 mRNA水平，而它降低了促炎细胞因子，诱导型一氧化氮合酶，核因子-Kappa的水平B P65，真核IF4e结合蛋白1，肌苷轻链激酶，BAX和肝脏中的Caspase-3 mRNA（P <0.05）。在延长的精子摄入量的情况下也发现了这些效果（P <0.05）。精霉可以减少促炎细胞因子和半胱天冬酶-3水平。总之，菲尔明可以促进屏障功能并改善氨基酸输送，可以提高免疫状态并抑制肝脏的凋亡。

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  • 来源
    《RSC Advances》 |2019年第20期|共9页
  • 作者

    Liu Guangmang; Zheng Jie; Cao Wei; Wu Xianjian; Jia Gang; Zhao Hua; Chen Xiaoling; Wu Caimei; Wang Jing;

  • 作者单位

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Inst Anim Nutr Chengdu 611130 Sichuan Peoples R China;

    Sichuan Agr Univ Maize Res Inst Chengdu 611130 Sichuan Peoples R China;

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