Phosphine-promoted [4+3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3+3] and [4+3] pathways

Liu Honglei; Lin Yan; Zhao Yan; Xiao Miaoren; Zhou Leijie; Wang Qijun; Zhang Cheng; Wang Dongqi; Kwon Ohyun; Guo Hongchao

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Phosphine-promoted [4+3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3+3] and [4+3] pathways

机译：磷酸促进的[4 + 3]用氮化萘酸乙酯的丙烯酸酯，用于合成四氢肽：膦依赖性[3 + 3]和[4 + 3]途径

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In this manuscript, phosphine-dependent [3 + 3] and [4 + 3] annulation reactions of allenoate with aziridines were disclosed. The alkyldiphenylphosphine-promoted [4 + 3] annulation of allenoate with aziridines has been achieved under mild conditions, providing biologically interesting functionalized tetrahydroazepines in moderate to excellent yield with moderate to excellent regioselectivity and diastereoselectivity.

机译：在该原稿中，公开了膦依赖性的[3 + 3]和[4 + 3]与氮化萘酸甲磺酸盐的环状反应。在温和的条件下，在温和的条件下实现了烷基苯基膦促进的甲磺酸盐的促进的[4 + 3]环状，在中等至优异的优异区域选择性和非对映选择性和非对映选择性的中等至优异的产率，提供生物学上有趣的官能化四氢肽。

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《RSC Advances》 |2019年第3期|共8页
作者
Liu Honglei; Lin Yan; Zhao Yan; Xiao Miaoren; Zhou Leijie; Wang Qijun; Zhang Cheng; Wang Dongqi; Kwon Ohyun; Guo Hongchao;
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作者单位

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

Chinese Acad Sci Inst High Energy Phys 19B Yuquan Lu Beijing 100049 Peoples R China;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

Chinese Acad Sci Inst High Energy Phys 19B Yuquan Lu Beijing 100049 Peoples R China;

Univ Calif Los Angeles Dept Chem &

Biochem Los Angeles CA 90095 USA;

China Agr Univ Dept Appl Chem Beijing 100193 Peoples R China;

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正文语种 eng
中图分类化学;
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1. Phosphine-promoted [4+3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3+3] and [4+3] pathways [J] . Liu Honglei, Lin Yan, Zhao Yan, RSC Advances . 2019,第3期

机译：磷酸促进的[4 + 3]用氮化萘酸乙酯的丙烯酸酯，用于合成四氢肽：膦依赖性[3 + 3]和[4 + 3]途径
2. Phosphine-promoted [4 + 3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3 + 3] and [4 + 3] pathways [J] . Honglei Liu, Yan Lin, Yan Zhao, RSC Advances . 2019,第3期

机译：膦促进的[4 + 3]环戊烯酸与氮丙啶的环合成，用于合成四氢a庚因：膦依赖的[3 + 3]和[4 + 3]途径
3. Phosphine-Catalyzed Enantioselective [4+3] Annulation of Allenoates with C,N-Cyclic Azomethine Imines: Synthesis of Quinazoline-Based Tricyclic Heterocycles [J] . Yuan Chunhao, Zhou Leijie, Xia Miaoren, Organic letters . 2016,第21期

机译：膦催化的C，N-环偶氮亚胺亚胺酸酯的对映体选择性[4 + 3]环：合成基于喹唑啉的三环杂环。
4. Trapping the Elusive Aza-Oxyallylic Cation Intermediate: Aza-[4+3] Cycloaddition Reactions and their Application Toward Target Directed Synthesis. [D] . Barnes, Korry Lee. 2014

机译：捕集难以捉摸的氮杂-羟基烯丙基阳离子中间体：氮杂-[4 + 3]环加成反应及其在目标直接合成中的应用。
5. Phosphine-Promoted 3 + 3 Annulations of Aziridines With Allenoates: Facile Entry Into Highly Functionalized Tetrahydropyridines [O] . Hongchao Guo, Qihai Xu, Ohyun Kwon -1

机译：膦促进的3 + 3氮杂环丙烷用的联烯酸酯的annulations：简易入世高度官能四氢吡啶
6. Phosphine-promoted 4 + 3 annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent 3 + 3 and 4 + 3 pathways [O] . Honglei Liu, Yan Lin, Yan Zhao, 2019

机译：磷酸促进的4 + 3用氮化萘酸乙酯的丙烯酸酯，用于合成四氢肽：膦依赖性3 + 3和4 + 3途径

Phosphine-promoted [4+3] annulation of allenoate with aziridines for synthesis of tetrahydroazepines: phosphine-dependent [3+3] and [4+3] pathways

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