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首页> 外文期刊>RSC Advances >Toward improved wound dressings: effects of polydopamine-decorated poly(lactic-co-glycolic acid) electrospinning incorporating basic fibroblast growth factor and ponericin G1
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Toward improved wound dressings: effects of polydopamine-decorated poly(lactic-co-glycolic acid) electrospinning incorporating basic fibroblast growth factor and ponericin G1

机译：朝向改善的伤口敷料：聚二胺装饰的聚（乳酸 - 共乙醇酸）静电纺丝掺入碱性成纤维细胞生长因子和Ponericin G1的影响

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Artificial dressings composed of degradable polymer materials have a wide range of applications in skin repair. The structure and properties, in particular, the antibacterial properties, of the material surface are crucial for biological processes such as cell adhesion, proliferation, and skin regeneration. In this study, we aimed to prepare poly(lactic-co-glycolic acid) (PLGA) nanofiber scaffolds modified by polydopamine using electrospinning technology in order to produce polydopamine-modified degradable PLGA nanocomposites. The polydopamine-PLGA scaffold was endowed with excellent protein adhesion ability through the cross-linking of two biologically active factors, basic fibroblast growth factor (bFGF) and ponericin G1, significantly improving skin repair ability. The electrospun nanofiber scaffold was shown to have a structure similar to that of the natural cell matrix and created a more favorable microenvironment for cell growth. Surface modification by polydopamine dramatically improved the hydrophilicity of the nanofiber scaffold, increasing its ability to absorb active factors and its biocompatibility. The bFGF and ponericin G1 loaded onto the scaffold surface (PDA-PLGA/bFGF/ponericin G1 nanofiber scaffold) strongly promoted the antibacterial and cell proliferation-promoting properties and greatly enhanced the adhesion and proliferation of cells on the scaffold surface. The nanofiber scaffold also promoted wound healing and tissue collagen production in a rat wound healing model. Together, these findings indicate that the polydopamine-PLGA/bFGF/ponericin G1 nanofiber scaffold exhibits good biocompatibility and antibacterial properties, suggesting that it possesses potential value for skin tissue regeneration applications.
机译：由可降解的聚合物材料组成的人造敷料在皮肤修复中具有广泛的应用。材料表面的结构和性质，特别是抗菌性，对生物方法如细胞粘附，增殖和皮肤再生是至关重要的。在该研究中，我们的目的是使用静电纺丝技术制备多莫多胺修饰的聚（乳酸二乙醇酸）（PLGA）纳米纤维支架，以制备多多胺改性可降解PLGA纳米复合材料。通过两种生物学活性因子，碱性成纤维细胞生长因子（BFGF）和Ponericin G1的交联，聚二氨胺-PLGA支架赋予优异的蛋白质粘附能力，显着提高了皮肤修复能力。示出了电纺纳米纤维支架的结构与天然细胞基质的结构类似，并产生更有利的微环境以进行细胞生长。聚二胺的表面改性显着改善了纳米纤维支架的亲水性，增加了吸收积极因子及其生物相容性的能力。加载到支架表面上的BFGF和PINERICIN G1（PDA-PLGA / BFGF / PINERICIN G1纳米纤维支架）强烈促进了抗菌和细胞增殖促进性能，大大提高了支架表面上细胞的粘附性和增殖。纳米纤维支架还促进了大鼠伤口愈合模型中的伤口愈合和组织胶原蛋白。这些发现表明，聚二胺-PLGA / BFGF / PINERICIN G1纳米纤维支架表现出良好的生物相容性和抗菌性能，表明它具有皮肤组织再生应用的潜在价值。

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    《RSC Advances》 |2019年第57期|共14页
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  • 中图分类 化学;
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