Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles

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Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles

机译：2-硫代酯胃泌素的合成和反应性：2-甲酰基吡咯的途径

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2-Functionalised pyrroles exhibit considerable synthetic utility. Herein, the synthesis and reactivity of 2-thionoester (-C(S)OR) pyrroles is reported. 2-Thionoester pyrroles were synthesised using a Knorr-type approach from aliphatic starting materials. 2-Thionoester pyrroles were reduced to the corresponding 2-formyl pyrroles, or the deuterated formyl variant, in one step using RANEY (R) nickel, thereby removing the need for the much-utilised hydrolysis/decarboxylation/formylation steps that are typically required to convert Knorr-type 2-carboxylate pyrroles into 2-formyl pyrroles. 2-Thionoester pyrroles proved tolerant of typical functional group interconversions for which the parent 2-carboxylate pyrroles have become known.

机译：2功能化的烟草表现出相当大的合成效用。在此，报告了2-硫代酯（-C或）胃肠杆菌的合成和反应性。使用来自脂族原料的knorr型方法合成2-硫代酯胃膏。使用Raney镍在一步中将2-硫代酯的胃泌素或氘代甲酰基变异减少，从而除去了通常需要的多种水解/脱羧/甲酰化步骤的需要将knorr-型2-羧酸纤维素转化为2-甲酰基吡咯。 2-硫代酯胃膏证明耐受母体2-羧酸吡咯的互联网的耐受性耐受性。

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《RSC Advances》 |2019年第54期|共8页
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1. Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles [J] . RSC Advances . 2019,第54期

机译：2-硫代酯胃泌素的合成和反应性：2-甲酰基吡咯的途径
2. Regioselective substituent effects upon the synthesis of dipyrrins from 2-formyl pyrroles [J] . Beh Michael H. R., Figliola Carlotta, Lund Kate-Lyn A. R., Canadian Journal of Chemistry . 2018,第7期

机译：从2-甲酰基吡咯的偶氯林合成的区域选择性取代基
3. Synthesis and Reactivity of Aziridines with Internal Dipolarophiles: An Approach to 1,4-Dihydrochromeno[4,3-b]pyrroles and 3-Methylenechromano[4,3-b]pyrroles [J] . Ribeiro Laia Fernanda M., Pinho e Melo Teresa M. V. D. Synthesis: International Journal of Methods in Synthetic Organic Chemistry . 2015,第18期

机译：氮丙啶类化合物与内部偶极亲和性的合成和反应性：一种1,4-二氢色酚[4,3-b]吡咯和3-亚甲基苯并[4,3-b]吡咯的制备方法
4. An efficient synthesis of 2-substituted pyrrole stable phosphorus ylides from reaction between pyrrole and acetylenic esters in the presence of triphenylphosphine in water-acetone media(Abstracts) [C] . Malek Taher Maghsoodlou, Nourollah Hazeri, Sayyed Mostafa Habibi Khorassani European Symposium on Organic Chemistry . 2007

机译：在水 - 丙酮培养基中的三苯基膦（摘要）中，在吡咯和乙炔酯之间的2取代吡咯稳定磷ylides中的高效合成。
5. Green chemistry in pyrrole synthesis. I. Solvent effect in Barton-Zard pyrrole synthesis: An improved synthesis of 3,4-dialkyl-1H-pyrrole-2-carboxylates. II. A novel route for the synthesis of pharmaceutically important pyrrole derivatives. [D] . Cherukuri, Sankara R. 2005

机译：吡咯合成中的绿色化学。 I.Barton-Zard吡咯合成中的溶剂作用：3，4-二烷基-1H-吡咯-2-羧酸酯的改进的合成。二。合成重要的吡咯衍生物的新途径。
6. A Biomimetic Route for the Construction of the 4+2 and 3+2 Core Skeletons of the Dimeric Pyrrole-Imidazole Alkaloids and the Asymmetric Synthesis of Ageliferins [O] . Xiao Wang, Xiaolei Wang, Xianghui Tan, -1

机译：仿生路线用于建设中的4 + 2和3 + 2的二聚吡咯咪唑生物碱和ageliferins的不对称合成的核心骨架
7. Synthesis of pentasubstituted 2-aryl pyrroles from boryl and stannyl alkynes via one-pot sequential Ti-catalyzed 2 + 2 + 1 pyrrole synthesis/cross coupling reactions [O] . Yukun Cheng, Channing K. Klein, Ian A. Tonks 2020

机译：通过单壶顺序Ti催化2 + 2 + 1吡咯合成/交叉偶联反应合成来自硼和甾烷基炔醇的五烷基化2-芳基吡咯。2 + 2 + 1吡咯合成/交叉偶联反应

Synthesis and reactivity of 2-thionoester pyrroles: a route to 2-formyl pyrroles

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