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首页> 外文期刊>RSC Advances >Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit
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Phytochemical composition and the cholinesterase and xanthine oxidase inhibitory properties of seed extracts from the Washingtonia filifera palm fruit

机译：从华盛顿亚洲菲尔德棕榈果实组成和胆碱酯酶和胆碱酯酶和黄嘌呤氧化酶抑制性质

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摘要

The chemical composition and biological properties of palm Washingtonia filifera (Lindl.) H. Wendl. seeds are seldom studied. Bearing this in mind, the seeds of W. filifera fruits were analysed for their fatty acid and phenolic composition and their antioxidant activity in addition to their cholinesterase and xanthine oxidase inhibitory activities. Seed extracts were revealed as a good source of phenolics with significant antioxidant activity. The phenolic profile mainly consisted of proanthocyanidins or procyanidin dimers B1-B4 among the major compounds. The highest butyrylcholinesterase inhibitory activity was found in the ethanolic extracts of seeds, with IC50 values of 13.73 +/- 1.31 mu g mL(-1). Seed alcoholic extracts also displayed interesting xanthine oxidase inhibitory activity, with IC50 values ranging between 75.2 +/- 17.0 mu g mL(-1) and 95.8 +/- 5.9 mu g mL(-1). Procyanidin B1, a major component in the extracts, could be an important contributor to that activity, as it was found to possess good xanthine oxidase inhibition capacity (IC50 value of 53.51 +/- 6.03 mu g mL(-1)). Docking studies were also performed to predict the binding sites of procyanidins B1 and B2 within the xanthine oxidase structure. In all, W. filifera seeds appear as a promising natural source for the extraction of bioactive compounds with antioxidant and butyrylcholinesterase as well as xanthine oxidase inhibitory potential.
机译：棕榈华盛顿菊（LINDL。）H. Wendl的化学成分及生物学性质。种子很少研究。考虑到这一点，除了它们的胆碱酯酶和黄嘌呤氧化酶抑制活性之外，对其脂肪酸和酚醛组合物的脂肪酸和酚醛组合物的种子分析了W.Fifera果实的种子。揭示种子提取物作为具有显着抗氧化活性的酚类源泉。酚醛曲线主要由主要化合物中的原花青素或原霉素二聚体B1-B4组成。在种子的乙醇提取物中发现了最高的丁二醇预算酶抑制活性，IC 50值为13.73 +/-1.31μg（-1）。种子酒精提取物也显示有趣的黄嘌呤氧化酶抑制活性，IC 50值在75.2 +/-17.0μmGml（-1）和95.8 +/-5.9μg（-1）之间。 Procyanidin B1，提取物中的主要成分，可能是该活动的重要因素，因为它被发现具有良好的黄嘌呤氧化酶抑制能力（IC 50值为53.51 +/-6.03μg（-1））。还进行了对接研究以预测黄嘌呤氧化酶结构内的原硝酸酯B1和B2的结合位点。总而言之，W.叶子种子作为抗氧化剂和丁酰基胆碱酯酶的生物活性化合物和黄嘌呤氧化酶抑制势的促进的有希望的自然来源。

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  • 来源
    《RSC Advances》 |2019年第37期|共10页
  • 作者

    Floris Sonia; Fais Antonella; Rosa Antonella; Piras Alessandra; Marzouki Hanen; Medda Rosaria; Gonzalez-Paramas Ana M.; Kumar Amit; Santos-Buelga Celestino; Era Benedetta;

  • 作者单位

    Univ Cagliari Dept Life &

    Environm Sci Monserrato CA Italy;

    Univ Cagliari Dept Life &

    Environm Sci Monserrato CA Italy;

    Univ Cagliari Dept Biomed Sci Monserrato CA Italy;

    Univ Cagliari Dept Chem &

    Geol Sci Monserrato CA Italy;

    Univ Monastir Lab Transmissible Dis &

    Biol Act Subst Fac Pharm Monastir Tunisia;

    Univ Cagliari Dept Life &

    Environm Sci Monserrato CA Italy;

    Univ Cagliari Dept Chem &

    Geol Sci Monserrato CA Italy;

    Univ Cagliari Dept Elect &

    Elect Engn Cagliari Italy;

    Univ Salamanca Grp Invest Polifenoles GIP USAL Salamanca Spain;

    Univ Cagliari Dept Life &

    Environm Sci Monserrato CA Italy;

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