A titanium tetrachloride-based effective methodology for the synthesis of dipeptides

Comande Alessandra; Greco Marianna; Belsito Emilia Lucia; Liguori Angelo; Leggio Antonella

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A titanium tetrachloride-based effective methodology for the synthesis of dipeptides

机译：基于四氯化钛的合成二肽的有效方法

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A series of dipeptide systems have been easily achieved through a TiCl4-assisted condensation reaction. The reaction of N-protected amino acids with amino acid methyl esters in pyridine and in the presence of TiCl4 furnished the corresponding dipeptides with high yields and diastereoselectivity. The reaction was successfully applied to amino acids protected on the alpha-amino function with different protecting groups. The adopted experimental conditions allowed preserving both the protecting groups on the alpha-amino function and on the side chain functionalities. Furthermore, the preservation of the stereochemical integrity at the amino acid chiral centres has been verified.

机译：通过TiCl 4辅助缩合反应容易地实现了一系列二肽系统。 N保护氨基酸与吡啶中的氨基酸甲酯的反应和TiCl4的存在具有高产率和非对映选择性的相应二肽。通过不同的保护基团成功地将反应应用于保护α-氨基函数上的氨基酸。所采用的实验条件允许在α-氨基函数和侧链函数上保持保护基团。此外，已经验证了氨基酸手性中心的立体化学完整性的保存。

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《RSC Advances》 |2019年第38期|共6页
作者
Comande Alessandra; Greco Marianna; Belsito Emilia Lucia; Liguori Angelo; Leggio Antonella;
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作者单位

Univ Calabria Dipartimento Farm &

Sci Salute &

Nutr Edificio Polifunz I-87036 Arcavacata Di Rende CS Italy;

Univ Calabria Dipartimento Farm &

Sci Salute &

Nutr Edificio Polifunz I-87036 Arcavacata Di Rende CS Italy;

Univ Calabria Dipartimento Farm &

Sci Salute &

Nutr Edificio Polifunz I-87036 Arcavacata Di Rende CS Italy;

Univ Calabria Dipartimento Farm &

Sci Salute &

Nutr Edificio Polifunz I-87036 Arcavacata Di Rende CS Italy;

Univ Calabria Dipartimento Farm &

Sci Salute &

Nutr Edificio Polifunz I-87036 Arcavacata Di Rende CS Italy;

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正文语种 eng
中图分类化学;
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1. A titanium tetrachloride-based effective methodology for the synthesis of dipeptides [J] . Comande Alessandra, Greco Marianna, Belsito Emilia Lucia, RSC Advances . 2019,第38期

机译：基于四氯化钛的合成二肽的有效方法
2. A titanium tetrachloride-based effective methodology for the synthesis of dipeptides [J] . Alessandra Comandè, Marianna Greco, Emilia Lucia Belsito, RSC Advances . 2019,第38期

机译：基于四氯化钛的有效二肽合成方法
3. A titanium tetrachloride-based effective methodology for the synthesis of dipeptides [J] . Alessandra Comandè, Marianna Greco, Emilia Lucia Belsito, RSC Advances . 2019,第38期

机译：基于四氯化钛的有效二肽合成方法
4. Solvent Assisted Room Temperature Synthesis of Magnetically Retrievable and Reusable Dipeptide Stabilized Nanocrystals for Suzuki-Miyaura Cross-Coupling [C] . Rajib Sarkar, Supriya Sasmal, Debasish Podder International Conference on Polymer-Solvent Complexes and Intercalates . 2016

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A titanium tetrachloride-based effective methodology for the synthesis of dipeptides

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