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Fe/Zn-modified tricalcium phosphate (TCP) biomaterials: preparation and biological properties

机译：Fe / Zn改性磷酸钙（TCP）生物材料：制备和生物学性质

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摘要

Bone repairing materials play an essential role in the repair treatment of bone defects. The presence of calcium phosphate invertebrates is of significance for bone repairing processes. However, the mechanical properties and osteogenic activities of many current calcium phosphate materials are not ideal, which limit their biological applications. Therefore, it is an effective alternative strategy to study the modification of calcium phosphate biomaterials to address these limitations. In this research, in order to enhance the biological performance of tricalcium phosphate (-TCP), metal species (Fe and Zn) modified -TCP materials through the co-precipitation method were successfully developed. The physical, chemical and biological properties of the binary composites were carefully studied for the first time. The bioactivities of the Fe-TCP and Zn-TCP were evaluated by simulating body fluid (SBF) immersion experiments, blood compatibility, and cytotoxicity tests. The findings demonstrated that the metal-TCP with excellent cytocompatibility and osteogenic properties shows good potential in medical applications.
机译：骨修复材料在骨缺陷的修复治疗中起重要作用。磷酸钙无脊椎动物的存在对于骨修复过程具有重要意义。然而，许多目前磷酸钙材料的机械性能和成骨活性并不理想，这限制了它们的生物应用。因此，研究磷酸钙生物材料改性以解决这些限制的有效替代策略。在该研究中，为了提高磷酸三钙（-TCP）的生物学性能，通过共沉淀法成功地开发了通过共沉淀法改性-TCP材料的金属物质（Fe和Zn）。第一时间仔细研究二元复合材料的物理，化学和生物学性质。通过模拟体液（SBF）浸渍实验，血液相容性和细胞毒性试验来评估Fe-TCP和Zn-TCP的生物活性。研究结果表明，具有优异细胞组合性和成骨特性的金属TCP在医疗应用中表现出良好的潜力。

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  • 来源
    《RSC Advances》 |2019年第2期|共9页
  • 作者

    Xie Lu; Yang Yuanyi; Fu Zhiqiang; Li Yunfei; Shi Jiacheng; Ma Daichuan; Liu Suilin; Luo Daibing;

  • 作者单位

    Sichuan Univ State Key Lab Oral Dis Natl Clin Res Ctr Oral Dis Dept Prosthodont West China Hosp Stomatol Chengdu 610041 Peoples R China;

    Sichuan Coll Architectural Technol Dept Mat Engn Deyang 618000 Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Mat Sci &

    Engn Chengdu 610064 Peoples R China;

    Sichuan Univ Sch Mat Sci &

    Engn Chengdu 610064 Peoples R China;

    Sichuan Univ Analyt &

    Testing Ctr Chengdu 610064 Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

    Sichuan Univ Sch Chem Engn Chengdu 610065 Sichuan Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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