• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Arctigenin prevents monocrotaline-induced pulmonary arterial hypertension in rats
【24h】

Arctigenin prevents monocrotaline-induced pulmonary arterial hypertension in rats

机译：芳替苯素可防止大鼠的偏异度诱导的肺动脉高血压

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The hallmark features of the development of pulmonary arterial hypertension (PAH) include the proliferation of pulmonary vascular smooth muscle cells, oxidative stress, inflammation, and pulmonary artery remodeling. Arctigenin is a bioactive component of Arctium lappa that exerts anti-inflammatory and antiproliferative effects in several diseases; however, its effects on pulmonary arteries are still unclear. This study aimed to investigate the efficacy of arctigenin to prevent PAH. Rats injected with monocrotaline (MCT) progressively developed PAH. Arctigenin treatment (50 mg per kg per day, intra-peritoneally) ameliorated right ventricular systolic pressure and pulmonary arterial remodeling, decreased the expression of inflammatory cytokines, and limited the proliferation of pulmonary vascular smooth muscle cells in lungs. Mechanistically, arctigenin effectively inhibited the MCT-induced elevation of NLRP3, caspase-1, and interleukin 1-beta expression in the lungs. These results indicate that arctigenin ameliorates MCT-induced PAH, at least in part, through exerting its anti-inflammatory, antioxidant, and antiproliferative effects, which inhibit the NLRP3 inflammasome signal pathway in rats.
机译：肺动脉高压（PAH）的发育的标志特征包括肺血管平滑肌细胞，氧化应激，炎症和肺动脉重塑的增殖。甲基氨基素是牛蒡子的生物活性成分，在几种疾病中施加抗炎和抗增殖作用;然而，它对肺动脉的影响尚不清楚。本研究旨在探讨氨基酮预防PAH的疗效。用偏霉素（MCT）注射大鼠逐步开发PAH。氨基酮治疗（每天每天50毫克，腹膜内）改善右心室收缩压和肺动脉重塑，降低了炎性细胞因子的表达，并限制了肺部肺血管平滑肌细胞的增殖。机械地，氨基酮有效地抑制了肺中NLRP3，Caspase-1和白细胞介素1-β表达的MCT诱导的升高。这些结果表明，抗原素至少部分地通过施加其抗炎，抗氧化剂和抗增殖作用来改善MCT诱导的PAH，其抑制大鼠NLRP3炎性信号通路。

著录项

  • 来源
    《RSC Advances》 |2019年第1期|共8页
  • 作者

    Jiang Wei-Long; Han Xiao; Zhang Yu-Feng; Xia Qing-Qing; Zhang Jia-Ming; Wang Feng;

  • 作者单位

    Nanjing Univ Chinese Med Jiangyin Hosp Jiangyin Hosp Tradit Chinese Med Dept Respirat Wuxi City 214400 Jiangsu Peoples R China;

    Shanghai Univ Med &

    Hlth Sci Jiading Dist Cent Hosp Dept Cardiol Shanghai 201800 Peoples R China;

    Nanjing Univ Chinese Med Jiangyin Hosp Jiangyin Hosp Tradit Chinese Med Dept Respirat Wuxi City 214400 Jiangsu Peoples R China;

    Nanjing Univ Chinese Med Jiangyin Hosp Jiangyin Hosp Tradit Chinese Med Dept Respirat Wuxi City 214400 Jiangsu Peoples R China;

    Nanjing Med Univ Wuxi Peoples Hosp Dept Emergency Wuxi City 214023 Jiangsu Peoples R China;

    Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Neurol Shanghai 200080 Peoples R China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号