Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

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Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

机译：生物测定引导纯纯化酪蛋白的酪蛋白髓质体的纯化和其抗炎活性

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Twelve undescribed sesquiterpenoids, fomitopins A-L (1-12), were isolated via bioassay-guided purification from the bracket fungus Fomitopsis pinicola (Sw.) P. Karst, and this fungus have been reported to exhibit anti-microbial and anti-inflammatory activities. The structures of 1-12 were elucidated by spectroscopic and spectrometric analyses and their absolute configurations were further confirmed by ECD simulations. Ten isolated compounds were evaluated for their anti-inflammatory potential and compound 11 exhibited the most significant inhibition of superoxide anion generation and elastase release with IC50 values of 0.81 +/- 0.15 and 0.74 +/- 0.12 mu M. These newly purified sesquiterpenoids could be potential candidates for further anti-inflammatory studies.

机译：通过从支架真菌髓鞘（SW.）P. karst的生物测定引导纯化，分离出FOMitopins A-L（1-12）的FOMitopins A-L（1-12），据报道这种真菌表现出抗微生物和抗炎活性。通过光谱和光谱分析阐明了1-12的结构，并通过ECD模拟进一步证实了它们的绝对构型。评估10个分离的化合物，对其抗炎潜力，化合物11表现出最显着的超氧化物阴离子产生和弹性蛋白酶释放的抑制，IC 50值为0.81 +/- 0.15和0.74 +/-0.12μm。这些新纯化的倍二萜类化合物可以是潜在的候选人进行进一步的抗炎研究。

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《RSC Advances》 |2019年第59期|共12页
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1. Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity [J] . RSC Advances . 2019,第59期

机译：生物测定引导纯纯化酪蛋白的酪蛋白髓质体的纯化和其抗炎活性
2. Overview of the Biological Activities of a Methanol Extract from Wild Red Belt Conk, Fomitopsis pinicola (Agaricomycetes), Fruiting Bodies from Central Italy [J] . Angelini Paola, Tirillini Bruno, Bistocchi Giancarlo, International Journal of Medicinal Mushrooms . 2018,第11期

机译：来自野生红皮带囊，肉豆蔻蛋白（姬松茸），意大利中部的甲醇提取物的生物活性概述
3. Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2 [J] . Yoshikawa K, Inoue M, Matsumoto Y, Journal of natural products . 2005,第1期

机译：臭果子实体中的羊毛脂三萜和三萜糖苷及其对COX-1和COX-2的抑制活性
4. Antioxidant Activities and Purification of Polysaccharide Extracted from the Fruiting Bodies of Phellinus Igniarius [C] . Wei CHENG, Jun-Zhe QIN International conference on agricultural engineering and food engineering . 2012

机译：桑黄子实体提取物中多糖的抗氧化活性及纯化
5. Comparative studies on the biological activities of selected Chinese medicinal fungi: Ganoderma species and Cordyceps species. An exploration of whether the different parts of their fruiting bodies bear different properties. [D] . Yue, Gar Lee Grace. 2006

机译：某些中药真菌：灵芝和冬虫夏草的生物活性比较研究。探索其子实体的不同部分是否具有不同的属性。
6. Chemical composition and biological activity of extracts from fruiting bodies and mycelial cultures of Fomitopsis betulina [O] . Katarzyna Sułkowska-Ziaja, Agnieszka Szewczyk, Agnieszka Galanty, -1

机译：山茱F子实体和菌丝体提取物的化学组成和生物学活性
7. Analysis of Amino Acids, Vitamins and Minerals of Fruiting Body of Fomitopsis pinicola [O] . J.L. Ding, H.J. Shin, W.S. Cha 2006

机译：Fomitopsis Pinicola果实体内氨基酸，维生素和矿物质分析

Bioassay-guided purification of sesquiterpenoids from the fruiting bodies of Fomitopsis pinicola and their anti-inflammatory activity

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