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首页> 外文期刊>RSC Advances >Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities
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Hyperpatulones A-F, polycyclic polyprenylated acylphloroglucinols from Hypericum patulum and their cytotoxic activities

机译：Hyperapatulons A-F，来自HyderumAl patulum的多环聚丙烯酰基乙酰苯吡酰氨基和它们的细胞毒性活性

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摘要

Six new compounds, hyperpatulones A-F (1-6), along with ten additional known related derivatives (7-16), were isolated from Hypericum patulum (Guttiferae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR), X-ray crystallography, electronic circular dichroism (ECD) spectroscopy and Rh-2(OCOCF3)(4)-induced ECD. All compounds were tested for their cytotoxic activities on human HepG-2, HeLa, MCF-7, and A549 cell lines via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Compound 5 exhibited significant cytotoxicities against HepG-2, HeLa and A549 cell lines with IC50 values of 9.52 +/- 0.27, 11.87 +/- 0.22 and 12.63 +/- 0.12 M, respectively.
机译：六种新化合物，HyperApatorons A-F（1-6）以及十种其他已知的相关衍生物（7-16），从Hypericum patulum（guttiferae）分离。 通过对光谱数据（IR，UV，Hresims，1D和2D NMR）的广泛分析，X射线晶体，电子圆形二色性（ECD）光谱和RH-2（OCOCF 3）（4）诱导的ECD，阐明了它们的结构。 通过3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴（MTT）测定，测试所有化合物对人HepG-2，Hela，MCF-7和A549细胞系的细胞毒性活性。 化合物5分别表现出对Hepg-2，Hela和A549细胞系的显着细胞毒性，IC 50值分别为9.52 +/- 0.27,11.87 +/- 0.22和12.63 +/- 0.12 m。

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  • 来源
    《RSC Advances》 |2019年第14期|共6页
  • 作者

    Wu Zhong-Nan; Niu Qian-Wen; Zhang Yu-Bo; Luo Ding; Li Qing-Guo; Li Ying-Ying; Kuang Guang-Kai; He Li-Jun; Wang Guo-Cai; Li Yao-Lan;

  • 作者单位

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Guangzhou Univ Chinese Med Sch Pharmaceut Sci Guangzhou 510006 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

    Jinan Univ Coll Pharm Inst Tradit Chinese Med Sc Nat Prod Guangdong Prov Key Lab Pharmacodynam Constituents Guangzhou 510632 Guangdong Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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