DABCO bond cleavage for the synthesis of piperazine derivatives

首页> 外文期刊>RSC Advances >DABCO bond cleavage for the synthesis of piperazine derivatives

【24h】

DABCO bond cleavage for the synthesis of piperazine derivatives

机译：Dabco键对哌嗪衍生物的合成

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The applications of DABCO (1,4-diazabicyclo[2.2.2]octane) in the synthesis of piperazine derivatives including biologically active compounds via C-N bond cleavage are investigated in this review. Different reagents such as alkyl halides, aryl(heteroary) halides, carboxylic acids, diaryliodonium salts, tosyl halides, activated alkynes, benzynes etc. were applied for the preparation of the corresponding quaternary ammonium salts of DABCO, which are very good electrophiles for various nucleophiles such as phenols, thiophenols, thiols, alcohols, aliphatic and aromatic amines, sulfinates, phthalimide, indoles, NaN3, triazole and terazoles, NaCN, enols and enolates, halides, carboxylic acid salts etc. Besides preactivated DABCO salts, the in situ activation of DABCO in multicomponent reactions is also an efficient tactic in synthetic organic chemistry for the diversity oriented synthesis of drug-like piperazine derivatives.

机译：在本综述中研究了Dabco（1,4-二氮杂双环[2.2.2]辛烷值）在哌嗪衍生物的合成中的应用，包括通过C-N键裂解的生物活性化合物。诸如烷基卤化物，芳基（杂芳基），羧酸，二芳基碘盐，甲硅烷基，活化的炔烃，苯苏斯等不同的试剂用于制备相应的Dabco季铵盐，这对于各种亲核试剂非常好的亲电子剂如酚类，噻吩，硫醇，醇，脂族和芳族胺，硫酸盐，邻苯二甲酰亚胺，吲哚，NaN 3，三唑和氮杂钛，NaCN，烯醇和烯醇化物，卤化物，羧酸盐等除去Dabco Salts之外，原位活化多组分反应中的DABCO也是合成有机化学的有效策略，用于多样化的药物样哌嗪衍生物的合成。

著录项

来源
《RSC Advances》 |2019年第62期|共24页
作者

展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类化学;
关键词

相似文献

外文文献
中文文献
专利

1. DABCO bond cleavage for the synthesis of piperazine derivatives [J] . RSC Advances . 2019,第62期

机译：Dabco键对哌嗪衍生物的合成
2. Direct Oxidative Cleavage of Multiple Csp3-H Bonds and a C-C Bond in 2-(Pyridin-2-yl)acetate Derivatives: Formal [3+1+1] Synthesis of 3-(Pyridin-2-yl)indolizine Skeletons [J] . Wu Xia, Zhao Peng, Geng Xiao, Organic letters . 2017,第12期

机译：在2-（吡啶-2-基）乙酸酯衍生物中的多种CSP3-H键的直接氧化裂解和C-C键：3-（Pyridin-2-基）吲嗪骨架的正式[3 + 1 + 1]合成
3. Synthesis of Polycyclic Furan and Chromene Derivatives via Cascade Reactions Enabled by Cleavage of Multiple C(sp(3))-F Bonds [J] . Xie Ting, Zhang Chen, Zhang Si-Xuan, Advanced synthesis & catalysis . 2020,第21期

机译：通过多次C（SP（3）） - F键合的级联反应来合成多环呋喃和铬烯衍生物
4. Low-Valent Ti tanium-Mediated Direct C–OH Bond Cleavage of Benzyl Alcohol Derivatives and Its Application to C–C Bond Formation [C] . Takuya Suga, Shoma Shimazu, Yut aka Uka j i 日本化学会春季年会講演予稿集 . 2018

机译：低价Ti唐尼米介导的苄醇衍生物的直接C-OH键切割及其在C-C键形成中的应用
5. Part I. Development of new organic synthetic methods: Palladium and copper catalyzed carbon-carbon, carbon-sulfur, carbon-nitrogen, and carbon-oxygen bond formation as well as DABCO-mediated stereospecific synthesis of acrylate ethers and amines. Part II. Design, synthesis and SAR studies of new classes of agents to treat drug-resistant bacteria, anthrax and tuberculosis infections. [D] . Kabir, Mohd Shahjahan. 2011

机译：第一部分：新的有机合成方法的开发：钯和铜催化的碳-碳，碳-硫，碳-氮和碳-氧键的形成，以及DABCO介导的丙烯酸酯醚和胺的立体有择合成。第二部分新型药物的设计，合成和SAR研究，用于治疗抗药性细菌，炭疽和肺结核感染。
6. Palladium(ii)-catalyzed synthesis of dibenzothiophene derivatives via the cleavage of carbon–sulfur and carbon–hydrogen bonds [O] . Mamoru Tobisu, Yoshihiro Masuya, Katsuaki Baba, 2016

机译：钯（ii）通过碳硫键和碳氢键的裂解催化合成二苯并噻吩衍生物
7. DABCO bond cleavage for the synthesis of piperazine derivatives [O] . Azim Ziyaei Halimehjani, Elham Badali 2019

机译：Dabco键对哌嗪衍生物的合成

DABCO bond cleavage for the synthesis of piperazine derivatives

摘要

著录项

相似文献

相关主题

期刊订阅