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Targeting regulation of tryptophan metabolism for colorectal cancer therapy: a systematic review

机译：靶向癌症治疗色氨酸代谢的靶向调节：系统审查

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摘要

Colorectal cancer (CRC) is one of the most malignant cancers resulting from abnormal metabolism alterations. As one of the essential amino acids, tryptophan has a variety of physiological functions, closely related to regulation of immune system, central nervous system, gastrointestinal nervous system and intestinal microflora. Colorectal cancer, a type of high-grade malignancy disease, stems from a variety of factors and often accompanies inflammatory reactions, dysbacteriosis, and metabolic disorders. Colorectal cancer accompanies inflammation and imbalance of intestinal microbiota and affects tryptophan metabolism. It is known that metabolites, rate-limiting enzymes, and ARH in tryptophan metabolism are associated with the development of CRC. Specifically, IDO1 may be a potential therapeutic target in colorectal cancer treatment. Furthermore, the reduction of tryptophan amount is proportional to the poor quality of life for colorectal cancer patients. This paper aims to discuss the role of tryptophan metabolism in a normal organism and investigate the relationship between this amino acid and colorectal cancer. This study is expected to provide theoretical support for research related to targeted therapy for colorectal cancer. Furthermore, strategies that modify tryptophan metabolism, effectively inhibiting tumor progression, may be more effective for CRC treatment.
机译：结肠直肠癌（CRC）是由代谢改变的异常导致的最恶性癌症之一。作为一种必要的氨基酸之一，色氨酸具有各种生理功能，与免疫系统的调节密切相关，中枢神经系统，胃肠神经系统和肠道微生物。结肠直肠癌，一种高档恶性疾病，源于各种因素，常伴伴有炎症反应，缺血性和代谢障碍。结直肠癌伴有肠道微生物症的炎症和失衡，影响色氨酸代谢。众所周知，色氨酸代谢中的代谢物，限流酶和ARH与CRC的发育有关。具体地，IDO1可以是结直肠癌治疗中的潜在治疗靶标。此外，色氨酸量的减少与结肠直肠癌患者的差的生活质量差。本文旨在讨论色氨酸代谢在正常生物中的作用，并研究该氨基酸和结直肠癌之间的关系。该研究预计将为与靶向治疗有关的结肠直肠癌有关的研究提供理论支持。此外，改变色氨酸代谢的策略有效抑制肿瘤进展，对CRC治疗更有效。

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  • 来源
    《RSC Advances》 |2019年第6期|共9页
  • 作者

    Zhang Hong-lian; Zhang Ai-hua; Miao Jian-hua; Sun Hui; Yan Guang-li; Wu Fang-fang; Wang Xi-jun;

  • 作者单位

    Guangxi Bot Garden Med Plant Natl Engn Lab Dev Southwestern Endangered Med Mat Nanning Guangxi Peoples R China;

    Heilongjiang Univ Chinese Med Sinoamer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Guangxi Bot Garden Med Plant Natl Engn Lab Dev Southwestern Endangered Med Mat Nanning Guangxi Peoples R China;

    Heilongjiang Univ Chinese Med Sinoamer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Heilongjiang Univ Chinese Med Sinoamer Chinmed Technol Collaborat Ctr Natl TCM Key Lab Serum Pharmacochem Lab Metab Chinmed Res Ctr State Adm TCM Dept Pharmaceut Ana Heping Rd 24 Harbin Heilongjiang Peoples R China;

    Guangxi Bot Garden Med Plant Natl Engn Lab Dev Southwestern Endangered Med Mat Nanning Guangxi Peoples R China;

    Guangxi Bot Garden Med Plant Natl Engn Lab Dev Southwestern Endangered Med Mat Nanning Guangxi Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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