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Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

机译：分散在Pluronic F127水凝胶中的超顺磁性氧化铁纳米粒子：局部应用中的潜在用途

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The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles (Fe3O4 NPs), and their incorporation in Pluronic F127 hydrogel with great potential for topical applications. Magnetite nanoparticles (Fe3O4 NPs) were synthesized by thermal decomposition of acetylacetonate iron (Fe(acac) 3), and coated with the thiol containing molecule mercaptosuccinic acid (MSA), leading to Fe3O4-MSA NPs. The obtained NPs were characterized using different techniques. The results showed that the Fe3O4-MSA NPs have a mean diameter of 11 nm, in the solid state, and superparamagnetic behavior at room temperature. Fe3O4-MSA NPs have an average hydrodynamic size of (78.0 +/- 0.9) nm, average size distribution (PDI) of 0.302 +/- 0.04, and zeta potential of (-22.10 +/- 0.55) mV. Free thiol groups on the Fe3O4-MSA NP surface were nitrosated by the addition of sodium nitrite, yielding S-nitrosated magnetic nanoparticles (Fe3O4-Snitroso-MSA NPs), which act as spontaneous NO donors upon S-N bond cleavage. The amount of (86.4 +/- 4.7) mmol of NO was released per gram of Fe3O4-S-nitroso-MSA NPs. In order to enhance NP dispersion, Fe3O4-MSA NPs were incorporated in Pluronic F127 hydrogel (3.4% w/w), and characterized using different techniques. Rheological measurements suggest a potential use for Fe3O4-MSA NPs dispersed in Pluronic hydrogel for topical applications. Atomic force microscopy (AFM) showed that the NPs are embedded within the Pluronic film while the X-ray photoelectron spectroscopy (XPS) spectrum of the Fe3O4-MSA NPs samples revealed the presence of iron, oxygen, carbon and sulfur, confirming the presence of MSA molecules on the NP surface.
机译：本研究专注于一氧化氮（NO）的合成和表征 - 重新分析氧化铁纳米粒子（Fe3O4 NPS）及其在Pluronic F127水凝胶中的掺入具有极大的局部应用的潜力。通过乙酰丙酮铁（Fe（ACAC）3）的热分解合成磁铁矿纳米颗粒（Fe 3 O 4 NPS），并涂覆含有分子巯基琥珀酸（MSA）的硫醇，导致Fe3O4-MSA NPS。使用不同的技术表征获得的NPS。结果表明，Fe3O4-MSA NPS在室温下具有11nm的平均直径为11nm，在室温下的超顺磁性行为。 Fe3O4-MSA NPS的平均水动力大小（78.0 +/- 0.9）NM，平均尺寸分​​布（PDI）为0.302 +/- 0.04，Zeta电位（-22.10 +/- 0.55）mV。通过加入亚硝酸钠（产生S-亚硝化磁性纳米粒子（Fe3O4-Snitroso-MSA NPS），将Fe 3 O 4-MSA NP表面上的游离硫醇基团硝化，其在S-N键切割时充当自发的供体。每克Fe3O4-S-Nitroso-MSA NPS释放（86.4 +/- 4.7）mmol的量。为了增强NP分散，Fe3O4-MSA NP掺入Pluronic F127水凝胶（3.4％w / w）中，并使用不同的技术表征。流变测量表明Fe3O4-MSA NPS分散在Pluronic水凝胶中的潜在用途，用于局部应用。原子力显微镜（AFM）显示NPS嵌入Pluronic薄膜内，而Fe3O4-MSA NPS样品的X射线光电子光谱（XPS）谱显示出铁，氧，碳和硫的存在，确认存在NP表面上的MSA分子。

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  • 来源
    《RSC Advances》 |2017年第24期|共8页
  • 作者

    Goncalves L. C.; Seabra A. B.; Pelegrino M. T.; de Araujo D. R.; Bernardes J. S.; Haddad P. S.;

  • 作者单位

    Univ Fed Sao Paulo Exact &

    Earth Sci Dept UNIFESP Diadema SP Brazil;

    Univ Fed Sao Paulo Exact &

    Earth Sci Dept UNIFESP Diadema SP Brazil;

    Univ Fed Sao Paulo Exact &

    Earth Sci Dept UNIFESP Diadema SP Brazil;

    Univ Fed ABC Human &

    Nat Sci Ctr Santo Andre SP Brazil;

    CNPEM Brazilian Ctr Res Energy &

    Mat Campinas SP Brazil;

    Univ Fed Sao Paulo Exact &

    Earth Sci Dept UNIFESP Diadema SP Brazil;

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