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首页> 外文期刊>RSC Advances >Cationic Salecan-based hydrogels for release of 5-fluorouracil
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Cationic Salecan-based hydrogels for release of 5-fluorouracil

机译：基于阳离子的Salecan水凝胶，用于释放5氟尿嘧啶

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摘要

Salecan, a new water-soluble beta-glucan, has excellent physicochemical and biological characteristics. Here, a series of pH-sensitive hydrogels based on Salecan grafted with [2-(methacryloxy)ethyl] trimethylammonium chloride were developed for controlled drug delivery. The successful preparation of the grafted hydrogels was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis. After that, rheology and scanning electron microscopy tests showed that the mechanical and morphological properties of these hydrogels were strongly influenced by the Salecan content. Moreover, the swelling behavior of the resulting hydrogels was systematically studied, and the results suggested that they exhibited pH sensitivity. Loading and delivery experiments demonstrated that 5-fluorouracil was efficiently encapsulated into the hydrogel matrices and released in a predictable manner via pH and Salecan dose control. Finally, cell viability and adhesion assays verified the cell compatibility of the designed hydrogels. Altogether, these attributes make the Salecan-based graft hydrogel a promising platform for controlled 5-fluorouracil delivery.
机译：Salecan是一种新的水溶性β-葡聚糖，具有优异的物理化学和生物学特性。这里，基于与[2-（甲基丙烯酰氧基）乙基]三甲基氯化物接枝的Salecan的一系列pH敏感水凝胶用于受控药物递送。通过傅里叶变换红外光谱，X射线衍射和热重分析证实了接枝水凝胶的成功制备。之后，流变学和扫描电子显微镜测试表明，这些水凝胶的机械和形态特性受到SALECAN含量的强烈影响。此外，系统地研究了所得水凝胶的溶胀行为，结果表明它们表现出pH敏感性。装载和递送实验证明，5-氟尿嘧啶有效地包封在水凝胶基质中并通过pH和Salecan剂量控制以可预测的方式释放。最后，细胞活力和粘合测定验证了设计的水凝胶的细胞相容性。完全，这些属性使基于Salecan的移植水凝胶成为受控5氟尿嘧啶递送的有希望平台。

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  • 来源
    《RSC Advances》 |2017年第24期|共11页
  • 作者

    Qi Xiaoliang; Li Junjian; Wei Wei; Zuo Gancheng; Su Ting; Pan Xihao; Zhang Jianfa; Dong Wei;

  • 作者单位

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Ctr Mol Metab Nanjing 210094 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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