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首页> 外文期刊>RSC Advances >Tumor targeted nanostructured lipid carrier co-delivering paclitaxel and indocyanine green for laser triggered synergetic therapy of cancer
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Tumor targeted nanostructured lipid carrier co-delivering paclitaxel and indocyanine green for laser triggered synergetic therapy of cancer

机译：肿瘤靶向纳米结构脂质载体共同输送紫杉醇和吲哚菁绿，用于激光触发癌症的协同治疗

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摘要

A mono approach to cancer therapy usually fails to achieve satisfactory results due to its limited killing effect. Nanostructured lipid carriers (NLCs) with high biocompatibility as well as tumor targetability were successfully designed and formulated in our study to co-deliver paclitaxel (PTX) and indocyanine green (ICG) for combined chemo and photodynamic therapy. ICG not only acted as an imaging reagent but also as a laser responsive agent to aid accelerated drug release under laser irritation. It has been demonstrated that our drug delivery system (DDS) not only significantly enhanced the stability of drugs, produced sufficient local ROS and triggered accelerated drug release upon laser irradiation, but also increased intracellular uptake of drugs and induced increased cytotoxicity in cancer cells via synergistic effects. Moreover, NLCs demonstrated excellent tumor targetability in tumor-bearing mice. Therefore, tumor targeted co-delivery of PTX and ICG mediated by NLCs could be a promising approach for further development as an effective strategy for cancer therapy.
机译：由于其杀伤效果有限，Mono癌症治疗方法通常无法实现令人满意的结果。纳米结构脂质载体（国家联络委员会）具有高生物相容性以及肿瘤靶向性成功地设计和配制在我们的研究合作提供紫杉醇（PTX）和联合化疗和光动力疗法吲哚青绿（ICG）。 ICG不仅作为成像试剂，而且作为激光响应剂，以在激光刺激下有助于加速的药物释放。已经证明，我们的药物递送系统（DDS）不仅显着提高了药物的稳定性，产生了足够的局部ROS并在激光照射时触发加速药物释放，而且增加了药物的细胞内摄取，并通过协同诱导癌细胞中的细胞毒性增加的细胞毒性增加效果。此外，NLC在携带肿瘤小鼠中表现出优异的肿瘤靶向性。因此，由NLC介导的PTX和ICG的肿瘤靶向共递送可能是进一步发展的有希望作为癌症治疗的有效策略的方法。

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  • 来源
    《RSC Advances》 |2017年第56期|共10页
  • 作者

    Ding Xuefang; Xu Xian; Zhao Ye; Zhang Lihui; Yu Yadong; Huang Fei; Yin Dezhou; Huang He;

  • 作者单位

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Coll Biotechnol &

    Pharmaceut Engn 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Sch Pharmaceut Sci 30 South Puzhu Rd Nanjing 211816 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 化学;
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