Neoansamycins from Streptomyces sp LZ35

Liu Mengyujie; Lu Chunhua; Tang Ruocong; Li Shanren; Wang Haoxin; Shen Yuemao

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Neoansamycins from Streptomyces sp LZ35

机译：来自streptomyces sp lz35的新生霉素

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Previously, activation of the cryptic nam gene cluster led to three new naphthalenic ansamycins with unprecedented n-pentyl and n-butyl side chains from the mutant Streptomyces sp. SR201nam1OE strain. In this study, we further characterized the products of the mutant strain and six new neoansamycin congeners, namely neoansamycins D-I (1-6), were elucidated. Among them, compounds 1-3 feature the conserved skeleton of neoansamycins B and C but with n-hexyl side chains, and 4-6 are modified neoansamycins with n-pentyl side chains, illustrating the biosynthetic plasticity and diverse post-PKS modifications of neoansamycins.

机译：以前，隐秘NAM基因簇的激活导致了具有前所未有的N-戊基和正戊酰侧链的三种新的萘胺，来自突变体链霉菌SP。 SR201NAM1OE应变。在这项研究中，我们进一步表征了突变菌株的产物和六种新的新生霉素同源物，即新生霉素D-1（1-6）被阐明。其中，化合物1-3特征在于新生霉素B和C的保守骨架，但用N-己基侧链，4-6个用N-戊基侧链改性新生霉素，说明了新生霉素的生物合成塑性和不同的PKS修饰。

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《RSC Advances》 |2017年第56期|共6页
作者
Liu Mengyujie; Lu Chunhua; Tang Ruocong; Li Shanren; Wang Haoxin; Shen Yuemao;
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Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ 44 West Wenhua Rd Jinan 250012 Shandong Peoples R China;

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ 44 West Wenhua Rd Jinan 250012 Shandong Peoples R China;

Shandong Univ State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ 44 West Wenhua Rd Jinan 250012 Shandong Peoples R China;

Shandong Univ State Key Lab Microbial Technol Jinan 250100 Shandong Peoples R China;

Shandong Univ Sch Pharmaceut Sci Key Lab Chem Biol Minist Educ 44 West Wenhua Rd Jinan 250012 Shandong Peoples R China;

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正文语种 eng
中图分类化学;
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1. Bioactive Compound from Streptomyces sp. KB1 TISTR2504 as Effective Disinfectant against Microorganisms [J] . Monthon Lertcanawanichakul, Kittisak Chawawisit 药剂与药理学：英文版 . 2021,第001期
2. Neoansamycins from Streptomyces sp LZ35 [J] . Liu Mengyujie, Lu Chunhua, Tang Ruocong, RSC Advances . 2017,第56期

机译：来自streptomyces sp lz35的新生霉素
3. In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp LZ35 [J] . Liu Chao, Zhu Jing, Li Yaoyao, Chembiochem: A European journal of chemical biology . 2015,第6期

机译：体外重建链霉菌sp LZ35中加蓬内酯类生物合成的PKS途径。
4. Overexpression of hgc1 increases the production and diversity of hygrocins in Streptomyces sp LZ35 [J] . Li Shanren, Lu Chunhua, Ou Jinhuan, RSC Advances . 2015,第102期

机译：HGC1的过度表达增加了Streptomyces SP LZ35中Hygrocins的生产和多样性
5. Study of Humic Acid and Multiantagonis of Streptomyces Sp, Trichoderma Sp Application Techniques for Horticulture Plant on Marginal Soil [C] . Penta Suryaminarsih, Wiwik Sri Harijani, Wanti Mindari, International Conference on Science and Technology . 2018

机译：植物酸及植物植物植物酸性酸和多目标研究边缘土园林园艺植物SP应用技术
6. Studies on biocontrol of Fusarium wilt of Cajanus cajan b Paenibacillus sp. D1 and Streptomyces sp. A6 [D] . Singh, Anil Kumar. 2010

机译：Cajanus cajan b Paenibacillus sp。枯萎病的生物防治研究。 D1和链霉菌sp。 A6
7. Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) from Streptomyces sp. LZ35 [O] . Xiulei Zhang, Guijun Shang, Lichuan Gu, 2014

机译：链霉菌二萜环辛抑素合酶（CYC）的结晶和初步X射线衍射分析。 LZ35
8. Activation of the silent neoansamycin biosynthetic gene cluster and hygrocin biosynthesis in Streptomyces sp. LZ35 [O] . 李善仁 2013

机译：链霉菌无声新霉素生物合成基因簇的激活和潮霉素生物合成。 LZ35

Neoansamycins from Streptomyces sp LZ35

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