Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

Safari Ensieh; Maryamabadi Ammar; Hasaninejad Alireza

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Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂

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A green and efficient one-pot, sequential, multi-component protocol has been developed for the synthesis of some novel symmetrical bis-spirooxindole derivatives from the reaction of isatins, dihalides, malono derivatives and C-H activated carbonyl compounds or ketene aminal derivatives in the presence of potassium carbonate (K2CO3) in polyethylene glycol 400 (PEG-400) as a biodegradable polymeric solvent at room temperature. In this research, a variety of bis-spiro-indoline-pyranopyranes, bis-spiroindoline-chromenes, bis-spiro-indoline-pyrido-pyrimidines, bis-spiro-indoline-imidazo-pyridines and bis-spiro-indoline-pyridines were obtained with excellent yields within short reaction time and without chromatographic separation.

机译：已经开发了一种绿色和有效的单罐，顺序，多组分方案，用于合成来自Isatins，二卤化物，Malono衍生物和Ch活性羰基化合物或酮阳离子衍生物在存在下的异抗的一些新的对称双螺辛吲哚衍生物在聚乙二醇400（PEG-400）中的碳酸钾（K2CO3）作为在室温下可生物降解的聚合物溶剂。在本研究中，获得了各种双螺吲哚-吡喃吡喃，Bis-Spiroinline-Chromens，Bis-Sporo-Indoline-Pyrido-嘧啶，Bis-Slio-Indoline-咪唑吡啶和双螺吲哚 - 吡啶和双螺吲哚 - 吡啶在短反应时间内具有优异的产量，而没有色谱分离。

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《RSC Advances》 |2017年第63期|共10页
作者
Safari Ensieh; Maryamabadi Ammar; Hasaninejad Alireza;
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Persian Gulf Univ Dept Chem Fac Sci Bushehr 7516913817 Iran;

Persian Gulf Univ Dept Chem Fac Sci Bushehr 7516913817 Iran;

Persian Gulf Univ Dept Chem Fac Sci Bushehr 7516913817 Iran;

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正文语种 eng
中图分类化学;
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1. Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent [J] . Safari Ensieh, Maryamabadi Ammar, Hasaninejad Alireza RSC Advances . 2017,第63期

机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂
2. Solvent-free, highly efficient one-pot multi-component synthesis of 1-amido- and 1-carbamato-alkyl naphthols/phenols catalyzed by ethylammonium nitrate as reusable ionic liquid under neat reaction condition at ambient temperature [J] . Shafeek A. R. Mulla, Tarek A. Salama, Mohsinkhan Y. Pathan Tetrahedron letters: The International Journal for the Rapid Publication of Preliminary Communications in Organic Chemistry . 2013,第7期

机译：在环境温度下，纯净的反应条件下，硝酸乙铵作为可重复使用的离子液体，无溶剂，高效，一锅多组分合成1-氨基和1-氨基甲酰基烷基萘酚/酚。
3. ZrCl4 as an efficient catalyst for one-pot synthesis of highly functionalized piperidines via multi-component organic reactions [J] . Aboonajmi Jasem, Mousavi Mir Rasul, Maghsoodlou Malek Taher, Research on Chemical Intermediates . 2015,第4期

机译：ZrCl4是通过多组分有机反应一锅合成高官能化哌啶的有效催化剂
4. Highly efficient, one-pot, solvent-free synthesis of highly substituted imidazoles using molecular iodine as catalyst [C] . Yi-Ming Ren, Chun Cai International Conference on Chemical, Material and Metallurgical Engineering . 2012

机译：使用分子碘作为催化剂高效，单罐，无溶剂合成高度取代的咪唑
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. Polyethylene Glycol (PEG-400): An Efficient and Recyclable Reaction Medium for the Synthesis of Pyrazolo34-bpyridin-6(7H)-one Derivatives [O] . Xiaoxing Zhong, Guolan Dou, Deming Wang 2013

机译：聚乙二醇（PEG-400）：一种高效且可循环利用的反应介质用于合成吡唑并34-b吡啶-6（7H）-一衍生物
7. Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent [O] . Ensieh Safari, Ammar Maryamabadi, Alireza Hasaninejad 2017

机译：高效，单罐合成新的双螺氧吲哚吲哚，通过PEG-400中的序列多组分反应作为可生物降解的溶剂

Highly efficient, one-pot synthesis of novel bis-spirooxindoles with skeletal diversity via sequential multi-component reaction in PEG-400 as a biodegradable solvent

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