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Ethyl acetate extract of crabapple fruit is the cholesterol-lowering fraction

机译：Crabapple水果的乙酸乙酯提取物是降胆固醇的级分

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Hypercholesterolemia is highly associated with cardiovascular diseases (CVDs) such as atherosclerosis. Our previous study showed that extracts of crabapple fruit may decrease serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-c) in high-fat diet-induced obese mice. To investigate which bioactive component is responsive for cholesterol-lowering effect in crabapples and whether the component has effects on atherosclerosis, three different chemical fractions were isolated from ethanol extract of crabapples, and obese C57BL/6 mice fed with a high-fat diet and arteriosclerotic low-density lipoprotein receptor deficiency (LDLR-/-) mice fed with a western-diet (WD) were involved in our pharmacological studies. The results showed that ethyl acetate extract of crabapple (EAC) significantly decreased serum TC in both DIO and LDLR-/- mice. EAC also improved obesity, insulin resistance, lipid accumulation in the liver tissue in the DIO mice and prevented atherosclerotic plaque formation in LDLR-/- mice. Mechanistic study showed that EAC increased cholesterol excretion in the feces of DIO and LDLR-/- mice, and elevated CYP7A1 mRNA in HepG2 cell and inhibited cholesterol accumulation in the cell membrane. Our data suggest that EAC may lower serum TC and block atherosclerotic plaque via the inhibition of intestinal cholesterol absorption and TC synthesis in the liver, and EAC may be used as a dietary supplement on hypercholesterolemia and atherosclerosis.
机译：高胆固醇血症与心血管疾病（CVDS）等高度相关，例如动脉粥样硬化。我们以前的研究表明，Crabapple果实的提取物可以在高脂肪饮食诱导的肥胖小鼠中降低血清总胆固醇（TC）和低密度脂蛋白胆固醇（LDL-C）。为了探讨哪些生物活性成分对胆固醇的抗胆固醇效果的响应性，以及组分是否对动脉粥样硬化有影响，其中三种不同的化学级分与乙醇提取物的乙醇提取物，并且肥胖的C57BL / 6小鼠用高脂饮食和动脉粥样硬化喂养用西方饮食（WD）喂养的低密度脂蛋白受体缺乏（LDLR - / - ）小鼠参与了我们的药理学研究。结果表明，DIO和LDLR - / - 小鼠的Crabapple（EAC）的乙酸乙酯提取物显着降低了血清TC。 EAC还提高了DIO小鼠肝组织中的肥胖，胰岛素抵抗，血脂积累，并在LDLR - / - 小鼠中预防动脉粥样硬化斑块形成。机械研究表明，EAC在DIO和LDLR - / - 小鼠的粪便中增加了胆固醇排泄，HEPG2细胞中的CYP7A1 mRNA升高，抑制细胞膜中的胆固醇积累。我们的数据表明，EAC可以通过抑制肝脏吸收和TC合成来降低血清TC和阻断动脉粥样硬化斑块，并且EAC可以用作高胆固醇血症和动脉粥样硬化的膳食补充剂。

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  • 来源
    《RSC Advances》 |2017年第68期|共11页
  • 作者

    Wang Dongshan; Wu Yingchun; Liu Chuhe; Wang Yahui; Li Yin; Luo Lingling; Zhao Yuanyuan; Ke Zunli; Huang Cheng; Fan Shengjie;

  • 作者单位

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

    Shanghai Univ Tradit Chinese Med Sch Pharm Shanghai 201203 Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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