Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

Wang Tao; Chen Huaiqiong; Wang Ren; Chen Zhengxing; Zhong Qixin

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Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

机译：改性水稻蛋白质的丁香酚的自乳化设计纳米递送系统，用于控制野生酸苯乙烷的控制释放

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The self-emulsification of oils containing dissolved solutes is not only an intriguing phenomenon but is also of practical interest in the delivery of agricultural chemicals and drugs. Herein, a facile one-step self-emulsification of eugenol with tunable release rates of encapsulated lipophilic compounds was enabled simply by gently mixing eugenol with modified rice proteins (MRPs). Due to binding with eugenol by hydrophobic interactions lowering the oil/water interfacial tension, MRPs underwent secondary structure changes and precipitated on eugenol droplets of nanoscale. Increasing the MRP : eugenol ratio enabled the formation of more porous interfacial films to increase the first-order release rate of eugenol and the resultant anti-proliferation activity of encapsulated caffeic acid phenethyl ester (CAPE) against HTC-116 human colorectal cancer cells. Therefore, novel emulsions with varied interfacial structures can be fabricated utilizing MRPs to control release characteristics and bioactivity of lipophilic compounds.

机译：含有溶解溶质的油的自乳化不仅是一种有趣的现象，而且对农业化学品和药物的交付也是实际兴趣。这里，通过用修饰的水稻蛋白（MRP）轻轻混合丁烯酚，使具有可调谐释放化合物的丁香酚具有可调谐释放速率的丁烯酚的容易一步自乳化。由于通过疏水相互作用与丁香酚的结合降低油/水界面张力，MRP接受二级结构的变化并沉淀在纳米戊烯醇液滴上。增加MRP：丁香酚比使得形成更多孔的界面薄膜，以增加丁香酚的一阶释放速率以及对HTC-116人结肠直肠癌细胞的包封的咖啡酸苯乙烷酯（Cape）的所得抗增殖活性。因此，可以利用MRP来制造具有变化的界面结构的新型乳液，以控制脂质化合物的释放特性和生物活性。

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来源
《RSC Advances》 |2017年第79期|共9页
作者
Wang Tao; Chen Huaiqiong; Wang Ren; Chen Zhengxing; Zhong Qixin;
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作者单位

Jiangnan Univ State Key Lab Food Sci &

Technol Wuxi 214122 Peoples R China;

Univ Tennessee Dept Food Sci &

Technol Knoxville TN 37996 USA;

Jiangnan Univ State Key Lab Food Sci &

Technol Wuxi 214122 Peoples R China;

Jiangnan Univ State Key Lab Food Sci &

Technol Wuxi 214122 Peoples R China;

Univ Tennessee Dept Food Sci &

Technol Knoxville TN 37996 USA;

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正文语种 eng
中图分类化学;
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1. Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester [J] . Wang Tao, Chen Huaiqiong, Wang Ren, RSC Advances . 2017,第79期

机译：改性水稻蛋白质的丁香酚的自乳化设计纳米递送系统，用于控制野生酸苯乙烷的控制释放
2. Poly (acrylic acid) grafted gelatin nanocarriers as swelling controlled drug delivery system for optimized release of paclitaxel from modified gelatin [J] . Pal Anjali, Bajpai Jaya, Bajpai A. K. Journal of drug delivery science and technology . 2018,第期

机译：聚（丙烯酸）接枝明胶纳米载体作为溶胀控制的药物递送系统，用于优化紫杉醇的紫杉醇释放
3. Functionalization of ginger derived nanoparticles with chitosan to design drug delivery system for controlled release of 5-amino salicylic acid (5-ASA) in treatment of inflammatory bowel diseases: An in vitro study [J] . Markam Riya, Bajpai A. K. Reactive & Functional Polymers . 2020,第Apra期

机译：用壳聚糖将生姜纳米颗粒功能化，以设计药物释放系统以控制5-氨基水杨酸（5-ASA）的释放，治疗炎症性肠病：一项体外研究
4. Caffeic Acid Phenethyl Ester Protect Mice Hepatic Damage Against Cadmium Exposure [C] . Fuxin Chen, Pin Gong International Conference on Environment Science and Biotechnology . 2013

机译：咖啡酸苯乙烯酯保护小鼠肝脏损伤对镉暴露
5. Modified Indian gums as hydrophilic matrices for oral controlled release drug delivery systems. [D] . Baweja, Jitendra. 2015

机译：改性印度树胶作为口服控释药物递送系统的亲水性基质。
6. Sulfonate-modified phenylboronic acid-rich nanoparticles as a novel mucoadhesive drug delivery system for vaginal administration of protein therapeutics: improved stability, mucin-dependent release and effective intravaginal placement [O] . ChunYan Li, ZhiGang Huang, ZheShuo Liu, 1988

机译：磺酸修饰的富含苯基硼酸的纳米颗粒，作为用于阴道给药的蛋白质治疗药物的新型粘膜粘附药物递送系统：提高了稳定性，黏蛋白依赖性释放和有效的阴道内放置
7. Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester [O] . Tao Wang, Huaiqiong Chen, Ren Wang, 2017

机译：改性水稻蛋白质的丁香酚的自乳化设计纳米递送系统，用于控制野生酸苯乙烷的控制释放
8. Synthesis of a Series of Caffeic Acid Phenethyl Amide (CAPA) Fluorinated Derivatives: Comparison of Cytoprotective Effects to Caffeic Acid Phenethyl Ester (CAPE). [R] . Yang, J., Marriner, G. A., Wang, X., 2010

机译：一系列咖啡酸苯乙酰胺（Capa）氟化衍生物的合成：对咖啡酸苯乙酯（CapE）的细胞保护作用的比较。

Self-emulsification of eugenol by modified rice proteins to design nano delivery systems for controlled release of caffeic acid phenethyl ester

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