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首页> 外文期刊>RSC Advances >Mussel-inspired deposition of copper on titanium for bacterial inhibition and enhanced osseointegration in a periprosthetic infection model
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Mussel-inspired deposition of copper on titanium for bacterial inhibition and enhanced osseointegration in a periprosthetic infection model

机译：乌塞尔风格的铜沉积钛的细菌抑制和增强骨髓细胞抑制作用中的渗透性模型

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摘要

Periprosthetic infection represents one of the most devastating complications in orthopedic surgeries. Implants that have both anti-bacterial and bone-forming capability and may function to simultaneously clear infection and repair bone defect, therefore, are highly desirable. In this study, titanium (Ti) substrates were fabricated deposited with different amounts of copper (Cu) using polydopamine (PDA)based chemical modification technology. In vitro, Ti implants that were treated with PDA and deposited with Cu (Ti-PDA-Cu) showed excellent antibacterial performance against both S. aureus and E. coli compared with pristine Ti. They also markedly promoted adhesion and spreading of MC3T3-E1 cells, implying good biocompatibility of such Ti-PDA-Cu materials. In vivo, results from an animal model of implant-related osteomyelitis clearly demonstrated that Ti-PDA-Cu implants not only effectively inhibited bacterial infection, but also promoted osseointegration at the bone/implant interface. Taken together, these findings show that Ti-PDA-Cu possesses outstanding biocompatibility and antibacterial activity, and are candidate materials for preventing periprosthetic infection.
机译：PeriproSthetth感染是骨科手术中最毁灭性的并发症之一。因此，植入物具有抗细菌和骨形成能力，并且可以同时清除感染和修复骨缺损，因此是非常理想的。在该研究中，使用基于多斑嗪（PDA）的化学改性技术，用不同量的铜（Cu）沉积钛（Ti）底物。在体外，用PDA处理并用Cu（Ti-PDA-Cu）处理的Ti植入物与原始Ti相比，对S.UUREUS和大肠杆菌进行了优异的抗菌性能。它们还显着促进了MC3T3-E1细胞的粘附和扩散，暗示了这种Ti-PDA-Cu材料的良好生物相容性。在体内，植入物相关骨髓炎的动物模型的结果清楚地证明Ti-PDA-Cu植入物不仅有效抑制细菌感染，而且还促进了骨/植入界面处的骨整合。这些发现表明，Ti-PDA-Cu具有出色的生物相容性和抗菌活性，并且是用于预防围堰感染的候选材料。

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  • 来源
    《RSC Advances》 |2017年第81期|共12页
  • 作者

    Wang Lei; Yang Xing; Cao Weiwei; Shi Chen; Zhou Pinghui; Li Qiang; Han Fengxuan; Sun Junying; Xing Xiaodong; Li Bin;

  • 作者单位

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Coll Chem Engn Nanjing 210094 Jiangsu Peoples R China;

    Univ Calif Los Angeles Dept Mat Sci &

    Engn Los Angeles CA 90024 USA;

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Coll Chem Engn Nanjing 210094 Jiangsu Peoples R China;

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

    Nanjing Univ Sci &

    Technol Coll Chem Engn Nanjing 210094 Jiangsu Peoples R China;

    Soochow Univ Inst Orthopaed Affiliated Hosp 1 Dept Orthopaed Surg South Campus 188 Shizi St 708 Renmin Rd Suzhou 215006 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 化学;
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