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In vivo time-domain diffuse correlation spectroscopy above the water absorption peak

机译:在水吸收峰上方的体内时域漫射相关光谱

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Time-domain diffuse correlation spectroscopy (TD-DCS) is a newly emerging optical technique that exploits pulsed, yet coherent light to non-invasively resolve the blood flow in depth. In this work, we have explored TD-DCS at longer wavelengths compared to those previously used in literature i.e., 750-850 nm). The measurements were performed using a custom-made titanium-sapphire mode-locked laser, operating at 1000 nm, and an InGaAs photomultiplier as a detector. Tissue-mimicking phantoms and in vivo measurements during arterial arm cuff occlusion in n = 4 adult volunteers were performed to demonstrate the proof of concept. We obtained a good signal-to-noise ratio, following the hemodynamics continuously with a relatively fast (1 Hz) sampling rate. In all the experiments, the auto-correlation functions show a decay rate approximately five-fold slower compared to shorter wavelengths. This work demonstrates the feasibility of in vivo TD-DCS in this spectral region and its potentiality for biomedical applications. (C) 2020 Optical Society of America
机译:时域漫射相关光谱(TD-DCS)是一种新出现的光学技术,用于脉冲,但相干的光线以非侵入性地解析血液流动深度。在这项工作中,与以前用于文献中使用的那些,我们已经探索了更长的波长的TD-DCS,即750-850 nm)。使用定制的钛 - 蓝宝石模式锁定激光器进行测量,以1000nm操作,以及作为检测器的INGAAS光电倍增管。在N = 4个成年志愿者中,组织模仿幽灵和在动脉臂袖扣期间的体内测量进行展示概念证明。我们获得了良好的信噪比,以相对较快(1 Hz)采样率连续地呈血液动力学。在所有实验中,与较短波长相比,自相关函数显示衰减速率大约五倍较慢。这项工作展示了在该光谱区域中体内TD-DC的可行性及其对生物医学应用的潜力。 (c)2020美国光学学会

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