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首页> 外文期刊>Optics Letters >Longitudinal elastic wave imaging using nanobomb optical coherence elastography
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Longitudinal elastic wave imaging using nanobomb optical coherence elastography

机译:使用纳米族光学相干弹性造影的纵向弹性波成像

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Wave-based optical coherence elastography (OCE) is a rapidly emerging technique for elasticity assessment of tissues having high displacement sensitivity and simple implementation. However, most current noncontact wave excitation techniques are unable to target a specific tissue site in 3D and rely on transversal scanning of the imaging beam. Here, we demonstrate that dye-loaded perfluorocarbon nanoparticles (nanobombs) excited by a pulsed laser can produce localized axially propagating longitudinal shear waves while adhering to the laser safety limit. A phase-correction method was developed and implemented to perform sensitive nanobomb elastography using a similar to 1.5 MHz Fourier domain mode-locking laser. The nanobomb activation was also monitored by detecting photoacoustic signals. The highly localized elastic waves detected by the nanobomb OCE suggest the possibility of high-resolution 3D elasto- graphic imaging. (C) 2019 Optical Society of America
机译:基于波的光学相干弹性术(OCE)是一种迅速的弹性评估,适用于具有高位移灵敏度和简单实现的组织的弹性评估。 然而,大多数电流非接触波激励技术不能瞄准3D中的特定组织部位并依赖于成像梁的横向扫描。 这里,我们证明了由脉冲激光激发的染料装载的全氟碳纳米颗粒(纳米瘤瘤)可以在粘附到激光安全极限时产生局部轴向传播的纵向剪切波。 开发并实施了相位校正方法,以使用类似于1.5MHz的傅里叶域模式锁定激光器进行敏感的纳米族弹性显影。 还通过检测光声信号监测纳米族活化。 纳米族OCE检测到的高度局部弹性波表明了高分辨率3D弹性图形成像的可能性。 (c)2019年光学学会

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