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The Study of the Chemical Synthesis and Preparation of Histone with Post-Translational Modifications

机译：翻译后修饰的组蛋白的化学合成与制备研究

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摘要

In the post-genomic era, more and more interests have been focusing on epigenetics. The histones studded with certain post-translational modifications (PTMs) are becoming one of the cores in protein chemical biology research. The biological generations and functions of these "histone codes", such as their structural diversity, sophisticated regulations and complex cross-talks, are gradually discovered but still waiting to be deciphered. However, to prepare enough amount of homogeneously modified histones remain a challenge for chemical biologists. To overcome the shortage of traditional expression, protein total synthesis, semi-synthesis, and unnatural amino acid incorporation are becoming major approaches to fulfill this goal. In this review, we will summarize some typical examples for chemical prepared modified histone proteins for further biological study. The introduction of synthetic chemistry into this realm largely exhibited the importance and potential of chemical tools in biological and biomedical fertile grounds.
机译：在后基因组时代，越来越多的兴趣集中在表观遗传学上。带有某些翻译后修饰（PTM）的组蛋白正成为蛋白质化学生物学研究的核心之一。这些“组蛋白密码”的生物学世代和功能，例如其结构多样性，复杂的规定和复杂的串扰，逐渐被发现，但仍在等待破译。然而，制备足够量的均质修饰的组蛋白仍然是化学生物学家的挑战。为了克服传统表达的不足，蛋白质全合成，半合成和非天然氨基酸掺入已成为实现该目标的主要方法。在这篇综述中，我们将总结化学制备的修饰组蛋白的一些典型实例，以供进一步生物学研究。将合成化学引入该领域在很大程度上展示了化学工具在生物和生物医学沃土中的重要性和潜力。

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