Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines

Gomha Sobhi M.; Riyadha Sayed M.; Abdalla Mohamed M.

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Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines

机译：溶剂滴磨法：高效合成，查尔酮，双查尔酮，偶氮和双偶氮碱的合成，DPPH自由基清除和抗糖尿病活性

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Highly efficient one-pot solvent-free grinding method was reported for synthesis of chalcones 3a-j, 5a,b, 7 and bis-chalcones 9, 11. Cyclodehydration of bis-chalcones 9, 11 and chalcones 3 with hydrazine derivatives under solvent-free grinding method afforded bis-pyrazolines 12a,b, 13a,b and pyrazoline derivatives 14a-g, respectively. In a similar manner, grinding of bis-chalcones 9, 11 and chalcones 3 with hydroxylamine hydrochloride under the employed reaction conditions gave bis-isoxazolines 15, 16 and isoxazoline derivatives 17a-e, respectively. The antioxidant activity of the selected products was studied using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) assay. Also, the antidiabetic activity of the selected products against normal and alloxan induced diabetic mice was evaluated.

机译：报道了一种高效的一锅无溶剂研磨方法，用于合成查尔酮3a-j，5a，b，7和双查尔酮9、11。在溶剂中，二肼9、11和查尔酮3与肼衍生物进行环脱水反应。用自由研磨法分别得到双吡唑啉12a，b，13a，b和吡唑啉衍生物14a-g。以类似的方式，在所采用的反应条件下用盐酸羟胺研磨双查尔酮9、11和查耳酮3，分别得到双异恶唑啉15、16和异恶唑啉衍生物17a-e。使用1，1-二苯基-2-吡啶并肼基自由基（DPPH）测定法研究了所选产品的抗氧化活性。此外，评估了所选产品对正常小鼠和四氧嘧啶诱导的糖尿病小鼠的抗糖尿病活性。

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《Current Organic Synthesis》 |2015年第2期|共9页
作者
Gomha Sobhi M.; Riyadha Sayed M.; Abdalla Mohamed M.;
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正文语种 eng
中图分类有机化学;
关键词
Anti-diabetic activity; antioxidant activity; bis-isoxazolines; bis-pyrazolines; enones; isoxazolines; pyrazolines; solvent-free grinding;

机译：抗糖尿病活性;抗氧化活性;双异恶唑啉;双吡唑啉;烯酮;异恶唑啉;吡唑啉;无溶剂研磨;

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1. Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines [J] . Gomha Sobhi M., Riyadha Sayed M., Abdalla Mohamed M. Current Organic Synthesis . 2015,第2期

机译：溶剂滴磨法：高效合成，查尔酮，双查尔酮，偶氮和双偶氮碱的合成，DPPH自由基清除和抗糖尿病活性
2. Detection and activity evaluation of radical scavenging compounds by using DPPH free radical and on-line HPLC-DPPH methods [J] . Bandoniene D, Murkovic M, Pfannhauser W, European food research and technology =: Zeitschrift fur Lebensmittel-Untersuchung und -Forschung. A . 2002,第2期

机译：使用DPPH自由基和在线HPLC-DPPH方法检测和清除自由基的化合物的活性
3. Synthesis of Heterocyclic Chalcone Derivatives and Their Radical Scavenging Ability Toward 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) Free Radicals [J] . Ki-Jun Hwang, Ho-Seok Kim, In-Cheol Han Bulletin of the Korean Chemical Society . 2012,第8期

机译：杂环查尔酮衍生物的合成及其对2,2-二苯基-1-吡啶并肼基（DPPH）自由基的自由基清除能力
4. Phytochemical screening and antioxidant activity of ethanolic extract and ethyl acetate fraction from basil leaf (Ocimum hasilicum L.) by DPPH radical scavenging method [C] . Warsi, A R Sholichah International Pharmacy Conference . 2018

机译：DPPH自由基清除方法从罗尼叶（OCiMimum Hasilicum L.）乙二醇提取物和乙酸乙酯馏分的植物化学筛选和抗氧化活性
5. Synthesis and in Vitro Antioxidant Activity Evaluation of 3-Carboxycoumarin Derivatives and QSAR Study of Their DPPH• Radical Scavenging Activity [O] . Francisco J. Martínez-Martínez, Rodrigo Said Razo-Hernández, Ana Lilia Peraza-Campos, 2012

机译：3-羧香豆素衍生物的合成体外抗氧化活性评价及DPPH•自由基清除活性的QSAR研究
6. Synthesis of Dihydroxylated Chalcone Derivatives with Diverse Substitution Patterns and Their Radical Scavenging Ability toward DPPH Free Radicals [O] . 2008

机译：具有多种取代模式的二羟基查尔酮衍生物的合成及其对DppH自由基的清除能力

Solvent-Drop Grinding Method: Efficient Synthesis, DPPH Radical Scavenging and Anti-diabetic Activities of Chalcones, bis-chalcones, Azolines, and bis-azolines

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