• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Microbiology: An International Journal >Temperature Change Induces the Expression of vuuA Encoding Vulnibactin Receptor and crp Encoding Cyclic AMP Receptor Protein in Vibrio vulnificus
【24h】

Temperature Change Induces the Expression of vuuA Encoding Vulnibactin Receptor and crp Encoding Cyclic AMP Receptor Protein in Vibrio vulnificus

机译：温度变化诱导vuuA编码Vulnibactin受体和crp编码环AMP受体蛋白在弧菌中的表达。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Upon entering the human body, Vibrio vulnificus, a gram-negative marine bacterium, must withstand a temperature change (TC) from 25 to 37 A degrees C. This bacterium acquires iron mainly via the vulnibactin receptor (VuuA)-mediated iron uptake system (IUS), which is under the positive control of cyclic AMP receptor protein (CRP), a global regulator responsible for catabolite repression. In this study, we examined the effect of TC on the expression of vuuA and crp, and the reciprocal relation between VuuA-mediated IUS and CRP under iron-limited conditions. Iron limitation increased vuuA expression but decreased crp expression. TC resulted in increased vuuA and crp expression. A crp or vuuA mutation reciprocally decreased vuuA or crp expression. TC could increase vuuA or crp expression even in a crp- or vuuA-mutated background. These results indicate that TC increases the expression of both vuuA and crp by facilitating metabolism under iron-limited conditions, and that CRP and VuuA-mediated IUS interact coordinately toward optimal metabolism in V. vulnificus.
机译：进入人体后，革兰氏阴性海洋细菌弧菌弧菌必须承受25至37摄氏度的温度变化（TC）。该细菌主要通过vulnibactin受体（VuuA）介导的铁吸收系统获得铁。 （IUS），它处于环状AMP受体蛋白（CRP）的积极控制之下，CRP是负责分解代谢物抑制的全球性调节剂。在这项研究中，我们检查了TC对铁限制条件下vuuA和crp表达的影响，以及VuuA介导的IUS和CRP之间的相互关系。铁限制增加了vuuA表达，但降低了crp表达。 TC导致vuuA和crp表达增加。 crp或vuuA突变会相应降低vuuA或crp表达。即使在crp或vuuA突变的背景下，TC也可以增加vuuA或crp表达。这些结果表明，TC通过在铁受限的条件下促进新陈代谢来增加vuuA和crp的表达，并且CRP和VuuA介导的IUS协同作用，可在创伤弧菌中实现最佳代谢。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号