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首页> 外文期刊>Surgical Endoscopy >Multimodal radiofrequency ablation versus laparoscopic hepatic resection for the treatment of primary hepatocellular carcinoma within Milan criteria in severely cirrhotic patients: long-term favorable outcomes over 10years
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Multimodal radiofrequency ablation versus laparoscopic hepatic resection for the treatment of primary hepatocellular carcinoma within Milan criteria in severely cirrhotic patients: long-term favorable outcomes over 10years

机译：多峰射频消融对严重肝硬化患者米兰标准治疗原发性肝细胞癌的腹腔镜肝切除术：10年来的长期有利结果

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BackgroundLess invasiveness is an important consideration for the treatment of hepatocellular carcinoma (HCC) especially in patients with severe cirrhosis.MethodsBetween April 2000 and September 2016, 100 patients with liver damage B underwent multimodal radiofrequency ablation (RFA; n=62) or laparoscopic hepatic resection (Lap-HR; n=38) for primary HCC as defined by the Milan criteria. We compared the operative outcomes and patients' survival between the two groups.ResultsThe RFA group showed worse liver functions as indicated by indocyanine green retention rate (32.9 vs. 22.4%; p0.0001) and serum albumin value (3.3 vs. 3.6g/dl; p=0.0029). As expected, RFA was less invasive, as indicated by the differences in operation time (166 vs. 288min.; p0.0001) and blood loss (8 vs. 377g; p0.0001). There was no significant difference in the morbidity rate between the two groups; however, the duration of hospital stay of the RFA group was significantly shorter (7 vs. 11 days; p=0.0002). There were no significant between-group differences regarding overall or disease-free survival.ConclusionMultimodal RFA for HCC in patients with severe cirrhosis is associated with less invasiveness and shorter hospital stays, with no compromise in the patients' survival. In patients with severe cirrhosis, it may be time to consider changing the standard treatment for primary HCC within the Milan criteria to multimodal RFA.
机译：背景无形的侵袭性是治疗肝细胞癌（HCC）的重要考虑因素，特别是在严重肝硬化患者中。患有2000年4月和2016年9月，肝损伤的100名患者B接受多式多数射频消融（RFA; n = 62）或腹腔镜肝切除术或腹腔镜肝切除（LAP-HR; N = 38）用于米兰标准所定义的主要HCC。我们比较了两组的手术结果和患者的生存。结果，RFA组表现出更差的肝功能，如吲哚菁绿色保留率所示（32.9 vs.2.4％; P <0.0001）和血清白蛋白值（3.3与3.6g / DL; p = 0.0029）。正如预期的那样，RFA较少侵入性，如操作时间的差异所示（166对288min; P＆ 0.0001）和失血（8 vs.377g; P <0.0001）。两组之间的发病率没有显着差异;然而，RFA组的住院时间持续时间明显缩短（7比11天; P = 0.0002）。关于总体或易病存活的组差异没有显着的差异。严重肝硬化患者的HCC患者的COMPlusimodal RFA与较少的侵入性和较短的医院住宿有关，患者存活率没有妥协。在严重肝硬化的患者中，可能需要考虑在米兰标准中改变原发性HCC的标准治疗，以便多峰RFA。

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