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首页> 外文期刊>Synthetic Communications >Chemistry of bicyclic 5-6 systems: Synthesis of oxazolo[3,2-a]pyridines and their salts with a ring-junction nitrogen atom
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Chemistry of bicyclic 5-6 systems: Synthesis of oxazolo[3,2-a]pyridines and their salts with a ring-junction nitrogen atom

机译：双环化学5-6系统：用环结氮原子合成恶唑[3,2-a]吡啶及其盐

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摘要

The present review highlights the synthetic procedures reported for the preparation of oxazolo[3,2-a]pyridines as a class of 5-6 bicyclic heterocycles with a nitrogen atom at the ring junction. The different sections included the synthesis of the investigated analogs through the reactions of (1) β-ketoesters with α,β-unsaturated ketones (2) d-oxoacids or esters or unsaturated carboxylic acids with glycinol derivatives (3) unsaturated ketoesters with enamines (4) ethoxymethylenes with amidoglycinol derivatives (5) pyridinium salts with phenylglycinol (6) Multicomponent reactions, and (7) Synthesis of tetracyclic systems. The aim of the present study is to demonstrate a synopsis of the synthesis of compounds containing oxazolo[3,2-a]pyridine skeleton with high yields using readily and accessible starting materials, and efficient synthetic routes until now. The stereochemistry of the obtained enantiopure heterocycles, the isolation of the isomers and the reaction mechanisms of the unexpected products are discussed.
机译：本综述凸显了报道的杂唑[3,2-A]吡啶作为5-6类双环杂曲面的氮原子在环结处的氮原子。不同的部分包括通过用α，β-酮酯（2）D-氧酸酯或酯或不饱和羧酸与甘氨酸衍生物（3）不饱和乙烯酯的反应合成所研究的类似物（1）β-酮酯的反应合成4）乙氧基甲基与氨基甲酰胺酚衍生物（5）吡啶鎓盐，具有苯基甘氨酸（6）多组分反应，和（7）四环系统的合成。本研究的目的是证明使用易于和可接近的起始材料的含有高产率高的含恶唑罗[3,2-A]吡啶骨架的化合物的概要，以及直到现在的高效途径。讨论了所得对映络杂环的立体化学，异构体的分离和意外产品的反应机制。

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