Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

Kharmawlong George Kupar; Nongrum Ridaphun; Chhetri Bhusan; Rani Urns World Star; Rahman Noimur; Yadav Arun Kumar; Nongkhlaw Rishanlang

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Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

机译：绿色和有效的单罐合成2,3-二氢喹唑啉-4（1H） - 它们和它们的Anthelmintic研究

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A facile and highly efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones derivatives has been developed by the condensation of anthranilamide with aldehydes using sulfonic acid functionalized l-Proline@Fe3O4 nanoparticles as a catalyst. The advantages of this protocol are easy recovery and reusability of the catalyst besides simple work-up procedure and short reaction time. In addition, the anthelmintic activities of some selective compounds were investigated and it was found that 2-phenyl-2,3-dihydroquinazolin-4(1H)-one exhibited profound anthelmintic activity against two helminth models.

机译：通过使用磺酸官能化的L-脯氨酸胺为催化剂，通过用磺酸官能化L-脯氨酸-Fe3O4纳米颗粒的氨基甲酰胺与醛的缩合而开发了2,3-二氢喹唑啉-4（1H）-4-4（1H）酮衍生物的容易和高效的单壶合成。除了简单的处理程序和短反应时间之外，该方案的优点是催化剂的易于恢复和可重用性。此外，研究了一些选择性化合物的扁平症活性，发现2-苯基-2,3-二氢喹唑啉-4（1H） - 酮与两种蠕虫模型表现出深性的细胞活性。

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来源
《Synthetic Communications》 |2019年第20期|共13页
作者
Kharmawlong George Kupar; Nongrum Ridaphun; Chhetri Bhusan; Rani Urns World Star; Rahman Noimur; Yadav Arun Kumar; Nongkhlaw Rishanlang;
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作者单位

North Eastern Hill Univ Ctr Adv Studies Dept Chem Shillong 793022 Meghalaya India;

North Eastern Hill Univ Ctr Adv Studies Dept Chem Shillong 793022 Meghalaya India;

North Eastern Hill Univ Dept Zool Shillong Meghalaya India;

North Eastern Hill Univ Ctr Adv Studies Dept Chem Shillong 793022 Meghalaya India;

North Eastern Hill Univ Ctr Adv Studies Dept Chem Shillong 793022 Meghalaya India;

North Eastern Hill Univ Dept Zool Shillong Meghalaya India;

North Eastern Hill Univ Ctr Adv Studies Dept Chem Shillong 793022 Meghalaya India;

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原文格式 PDF
正文语种 eng
中图分类有机化学;
关键词
2; 3-Dihydroquinazolin-4(1H)-ones; anthranilamide; chlorosulfonic acid; functionalized organo-nanocatalyst; magnetic nanocatalyst;

机译：2;3-二氢喹唑啉-4（1H） - 酮;苯胺酸;氯磺酸;官能化有机纳米催化剂;磁性纳米催化剂;

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专利

1. Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies [J] . Kharmawlong George Kupar, Nongrum Ridaphun, Chhetri Bhusan, Synthetic Communications . 2019,第17a20期

机译：绿色和有效的单罐合成2,3-二氢喹唑啉-4（1H） - 它们和它们的Anthelmintic研究
2. Nano-indium oxide: An efficient catalyst for one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones with a greener prospect [J] . Sougata Santra, Matiur Rahman, Anupam Roy Catalysis Communications . 2014,第Null期

机译：纳米氧化铟：一锅合成2,3-二氢喹唑啉-4（1H）-有效的催化剂，具有绿色前景
3. KCC-1/Pr-SO3H: an efficient heterogeneous catalyst for green and one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-one [J] . Sajjad Azizi, Jafar Soleymani, Mohammad Hasanzadeh Nanocomposites . 2020,第1期

机译：KCC-1 / PR-SO3H：用于绿色和单盆合成的有效的异构催化剂2,3-二氢喹唑啉-4（1H） - ONE
4. ONE-POT MULTICOMPONENT SYNTHESIS of 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES USING SILICA-SUPPORTED PREYSSLER NANOPARTICLES AS A NOVEL, ECO-FRIENDLY and GREEN CATALYST [C] . Fatemeh F. Bamoharram, Majid M. Heravi, Mina Roshani, 6th international conference on environmental catalysis : Abstract book . 2010

机译：一键多组分合成3,4-二氢吡啶酮N-2（1H）-使用二氧化硅支撑的PreySSLer纳米粒子作为新型，环保和绿色催化剂
5. New developments toward the synthesis of heterocycles and applications in green chemistry. I. A simple and essentially one-pot synthesis of N-aminated heterocycles using phase transfer catalyst (Aliquat-336). II. Synthesis of pharmaceutically important pyrrole derivatives. III. Applications in green chemistry: Surfactant-mediated environmentally friendly cleavage of aromatic esters and trans-esterification under solvent-free neutral conditions . [D] . Patel, Nitinchandra. 2005

机译：杂环合成的新进展及其在绿色化学中的应用。 I.使用相转移催化剂（Aliquat-336）简单且基本上一锅合成N-胺化的杂环。二。药学上重要的吡咯衍生物的合成。三，在绿色化学中的应用：在无溶剂的中性条件下，表面活性剂介导的环境友好的芳族酯裂解和酯交换反应。
6. An Efficient One-Pot Green Protocol for the Synthesis of 5-Unsubstituted 34-Dihydropyrimidin-2(1H)-Ones Using Recyclable Amberlyst 15 DRY as a Heterogeneous Catalyst via Three-Component Biginelli-Like Reaction [O] . Srinivasa Rao Jetti, Divya Verma, Shubha Jain 2012

机译：一种高效的一锅绿色协议使用可回收的Amberlyst 15 DRY作为三元类似Biginelli相似反应的多相催化剂用于合成5-Un取代的34-Dihydropyrimidin-2（1H）-
7. Cerium (IV) sulfate: A highly efficient reusable heterogeneous catalyst for the one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones under solvent-free conditions [O] . Abolghasem Davoodnia, Maryam Khashi, Niloofar Tavakoli-Hoseini 2014

机译：硫酸铈（iv）硫酸盐：在无溶剂条件下，用于1罐合成的2,3-二氢喹唑啉-4（1h）酮的高效可再熔断的非均相催化剂

Green and efficient one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and their anthelmintic studies

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