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Histone Modifications in Ageing and Lifespan Regulation

机译：老化和寿命调节中的组蛋白修饰

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Ageing has been associated with structural changes in chromatin. At the molecular level, multiple histone modifications with established epigenetic mechanisms have been connected to the regulation of lifespan. Here, we review the changes in histone modification profiles during ageing and their possible functional contribution to ageing and lifespan regulation. We brief the state of the knowledge on marks associated with both repressive (H3K9me3, H3K9me2, H3K27me3) and active chromatin (H3K4me3, H3K36me3, H3K56ac, H4K16ac, H2Bub). We further explore new his-tone modifications that emerged as lifespan-regulating candidates from a recent screen in yeast. Next, we comment on protein arginine methylation and GlcNAcylation, exploring their potential linksto ageing. Finally, we provide a perspective on integrative approaches and methodological advances that might aid our pursuit of the epigenetic mechanisms ofageing.
机译：老化与染色质的结构变化有关。在分子水平上，具有确定的表观遗传机制的多个组蛋白修饰已与寿命调节相关。在这里，我们回顾了老化过程中组蛋白修饰谱的变化及其对衰老和寿命调节的可能作用。我们简要介绍了与抑制性（H3K9me3，H3K9me2，H3K27me3）和活性染色质（H3K4me3，H3K36me3，H3K56ac，H4K16ac，H2Bub）相关的标记的知识状态。我们进一步探索了新的组蛋白修饰，这些修饰是从最近在酵母中筛选出来的可调节寿命的候选物。接下来，我们评论蛋白质精氨酸甲基化和GlcNAcylation，探索它们与衰老的潜在联系。最后，我们提供了关于整合方法和方法学进展的观点，这些方法可能有助于我们追求衰老的表观遗传机制。

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