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首页> 外文期刊>Pediatric blood & cancer >Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study
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Psychological risk in long‐term survivors of childhood acute lymphoblastic leukemia and its association with functional health status: A PETALE cohort study

机译：儿童急性淋巴细胞白血病长期幸存者的心理风险及其与功能健康状况的关系：Petale队列研究

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Abstract Background Recent research has suggested that long‐term pediatric cancer survivors were at risk of important physical and psychological morbidities. To date, we do not know to what extent functional health status contributes to psychological risk and which domains are most important. The aim of this study was to systematically explore which functional domain could explain anxiety, depression, and distress symptoms. Procedure We used data available for 105 adolescents and 182 adults successfully treated for childhood acute lymphoblastic leukemia at two Canadian sites part of the PETALE cohort. Participants were ≥5 years postdiagnosis, aged 22 ± 6 years, 52% female, and 49% acute lymphoblastic leukemia high‐risk status. The contribution of health functional status (15D/16D questionnaires) to self‐reported anxiety, depression, and distress (Beck scales and distress thermometer) was evaluated using adjusted logistic regression models. Results Prevalence rates found for mild–severe anxiety, depression, and distress were 14%, 21%, and 30% among adolescents and 27%, 20%, and 19% among adults. Frequent health domains associated with psychological risk were sleeping and breathing in adolescents, and vitality/fatigue, discomfort/symptoms, mental function, and sleeping in adults. Mental function was systematically associated with psychological risk across age groups (median OR?=?10.00, 95% CI 3.01–33.71). Exploratory mediation bootstrapping analyses suggested that the effect on psychological risk of overall health status and mental function problems was partly explained by social/work/school functioning. Conclusion The results identified important functional health domains that could be targeted for interventions preventing psychological risk: vitality/fatigue, discomfort/symptoms, sleeping, and mental function issues. Health domains probably affect mood partly by limiting social/work/school functioning.
机译：摘要背景最近的研究表明，长期的儿童癌症幸存者在重要的生理和心理的发病率风险。迄今为止，我们不知道到什么程度功能的健康状况有助于心理风险和领域是最重要的。这项研究的目的是系统地探索其功能结构域可以解释焦虑，抑郁和痛苦症状。过程我们使用可用于105名青少年和成人182在PETALE队列的两个加拿大的网站部分成功治疗儿童急性淋巴细胞白血病的数据。参加者≥5年诊断后，年龄22±6岁，52％为女性，和49％的急性淋巴细胞白血病的高危状态。使用调整逻辑回归模型的健康功能状态（15D / 16D问卷），以自我报告的焦虑，抑郁和痛苦（贝克量表和窘迫温度计）的贡献进行了评价。结果发现，对于轻度，重度焦虑症，抑郁症，而苦恼的患病率分别为14％，21％，以及青少年和27％，20％，其中30％，成年人中19％。心理风险的频繁健康领域正在睡觉和呼吸的青少年，活力/疲劳，不适/症状，心理功能，并在成人睡觉。心理功能进行了系统与各年龄组心理风险（中位数OR？=？10.00，95％CI 3.01-33.71）相关联。探索调解引导分析表明，对整体健康状况和心理功能问题，心理风险的影响部分是由社会/工作/学校功能解释。结论发现了重要的功能性保健领域的结果，可以有针对性地进行干预预防心理风险：活力/疲劳，不适/症状，睡眠和心理功能的问题。卫生领域可能部分是通过限制社会/工作/学校的运作影响心情。

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