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首页> 外文期刊>Physics in medicine and biology. >Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer
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Shell feature: a new radiomics descriptor for predicting distant failure after radiotherapy in non-small cell lung cancer and cervix cancer

机译：壳体特征：一种新的辐射瘤描述符，用于预测非小细胞肺癌和子宫颈癌的放射治疗后的遥远衰竭

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摘要

Distant failure is the main cause of human cancer-related mortalities. To develop a model for predicting distant failure in non-small cell lung cancer (NSCLC) and cervix cancer (CC) patients, a shell feature, consisting of outer voxels around the tumor boundary, was constructed using pre-treatment positron emission tomography (PET) images from 48 NSCLC patients received stereotactic body radiation therapy and 52 CC patients underwent external beam radiation therapy and concurrent chemotherapy followed with high-dose-rate intracavitary brachytherapy. The hypothesis behind this feature is that non-invasive and invasive tumors may have different morphologic patterns in the tumor periphery, in turn reflecting the differences in radiological presentations in the PET images. The utility of the shell was evaluated by the support vector machine classifier in comparison with intensity, geometry, gray level co-occurrence matrix-based texture, neighborhood gray tone difference matrix-based texture, and a combination of these four features. The results were assessed in terms of accuracy, sensitivity, specificity, and AUC. Collectively, the shell feature showed better predictive performance than all the other features for distant failure prediction in both NSCLC and CC cohorts.
机译：遥远的失败是人类癌症相关死亡的主要原因。为了开发用于预测非小细胞肺癌（NSCLC）和宫颈癌（CC）患者的远处失败的模型，使用预处理正电子排放断层扫描构建（PET）构建由肿瘤边界周围的外体素组成的壳特征（PET ）48个NSCLC患者的图像接受了立体定向体放射治疗和52名CC患者接受外梁放射治疗和同时化疗，随后具有高剂量速率的内部近距离放射治疗。该特征背后的假设是肿瘤周边的非侵入性和侵入性肿瘤可能在肿瘤周边具有不同的形态图案，反过来反映了PET图像中的放射性呈现的差异。基于强度，几何，灰度级共生发生矩阵的基于邻灰灰色差矩阵的纹理，基于强度，几何，基于矩阵的纹理和基于这四个特征的组合，由支持向量机分类器评估外壳的效用。结果在准确性，敏感度，特异性和AUC方面进行了评估。集体，Shell功能显示出比NSCLC和CC队列中的远程故障预测的所有其他特征更好的预测性能。

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  • 来源
    《Physics in medicine and biology.》 |2018年第9期|共17页
  • 作者

    Hao Hongxia; Zhou Zhiguo; Li Shulong; Maquilan Genevieve; Folkert Michael R.; Iyengar Puneeth; Westover Kenneth D.; Albuquerque Kevin; Liu Fang; Choy Hak; Timmerman Robert; Yang Lin; Wang Jing;

  • 作者单位

    Xidian Univ Sch Comp Sci &

    Technol Xian 710071 Shaanxi Peoples R China;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Southern Med Univ Sch Biomed Engn Guangzhou 510515 Guangdong Peoples R China;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Xidian Univ Sch Comp Sci &

    Technol Xian 710071 Shaanxi Peoples R China;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

    Chinese Acad Med Sci Canc Hosp Natl Canc Ctr Dept Pathol Beijing 100021 Peoples R China;

    Univ Texas Southwestern Med Ctr Dallas Dept Radiat Oncol Dallas TX 75235 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 R35;
  • 关键词

    NSCLC; cervix cancer; radiomics; distant failure; shell;

    机译：NSCLC;子宫颈癌;辐射瘤;遥远的失败;壳;

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