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首页> 外文期刊>Physics in medicine and biology. >In vivo optoacoustic temperature imaging for image-guided cryotherapy of prostate cancer
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In vivo optoacoustic temperature imaging for image-guided cryotherapy of prostate cancer

机译：在体内光声温度成像中，用于癌前列腺癌的图像引导冷冻疗法

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摘要

The objective of this study is to demonstrate in vivo the feasibility of optoacoustic temperature imaging during cryotherapy of prostate cancer. We developed a preclinical prototype optoacoustic temperature imager that included pulsed optical excitation at a wavelength of 805 nm, a modified clinical transrectal ultrasound probe, a parallel data acquisition system, image processing and visualization software. Cryotherapy of a canine prostate was performed in vivo using a commercial clinical system, Cryocare (R) CS, with an integrated ultrasound imaging. The universal temperature-dependent optoacoustic response of blood was employed to convert reconstructed optoacoustic images to temperature maps. Optoacoustic imaging of temperature during prostate cryotherapy was performed in the longitudinal view over a region of 30 mm (long) x 10 mm (deep) that covered the rectum, the Denonvilliers fascia, and the posterior portion of the treated gland. The transrectal optoacoustic images showed high-contrast vascularized regions, which were used for quantitative estimation of local temperature profiles. The constructed temperature maps and their temporal dynamics were consistent with the arrangement of the cryoprobe and readouts of the thermal needle sensors. The temporal profiles of the readouts from the thermal needle sensors and the temporal profile estimated from the normalized optoacoustic intensity of the selected vascularized region showed significant resemblance, except for the initial overshoot, that may be explained as a result of the physiological thermoregulatory compensation. The temperature was mapped with errors not exceeding +/- 2 degrees C (standard deviation) consistent with the clinical requirements for monitoring cryotherapy of the prostate. In vivo results showed that the optoacoustic temperature imaging is a promising non-invasive technique for real-time imaging of tissue temperature during cryotherapy of prostate cancer, which can be combined with transrectal ultrasound-the current standard for guiding clinical cryotherapy procedure.
机译：本研究的目的是在体内证明光声温度成像在前列腺癌冷冻疗法期间的可行性。我们开发了一种突出的原型光声温度成像仪，其包括805nm的波长，修改的临床转基出超声探头，并行数据采集系统，图像处理和可视化软件的波长脉冲光学激发。使用商业临床系统，Croudocare（R）CS，具有集成的超声成像，在体内进行犬前列腺的冷冻疗法。采用血液的通用温度依赖性光声反应将重建的光声图像转换为温度图。前列腺冷冻疗法期间温度的光​​声成像在覆盖直肠，DENONVILLIERS FASCIA和经过处理的腺体的后部的区域的纵向视图中进行。经癌电神声图像显示出高对比度血管化区域，用于定量估计局部温度谱。构造的温度图及其时间动态与热针传感器的冷冻探针和读数的布置一致。除了初始过冲之外，来自热针传感器的读出和从所选血管化区域的归一化光声强度估计的读出的时间轮廓显示出显着的相似性，其可以通过生理热调节性补偿来解释。温度呈现出不超过+/- 2摄氏度（标准偏差）的误差，与监测前列腺冷冻疗法的临床要求一致。在体内结果表明，光声温度成像是一种有前途的非侵入性技术，用于在前列腺癌冷冻治疗期间的组织温度实时成像，这可以与经电委超声 - 目前标准用于指导临床冷冻疗法。

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