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首页> 外文会议>Photons Plus Ultrasound: Imaging and Sensing 2006; Progress in Biomedical Optics and Imaging; vol.7, no.9 >In vivo Testing of Laser Optoacoustic System for Image-Guided Biopsy of Prostate
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In vivo Testing of Laser Optoacoustic System for Image-Guided Biopsy of Prostate

机译：激光声光系统在前列腺图像引导下的活检

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We have developed and used a laser optoacoustic imaging system with transrectal probe (LOIS-P) for detection of mechanical lesions in canine prostates in vivo. LOIS images have been acquired with a 128-channel transrectal probe and a 32-channel data acquisition system. Optoacoustic images showed a strong contrast enhancement for a blood containing lesion, when compared with ultrasound images. Our studies demonstrated that sufficient optoacoustic contrast exists between blood containing lesion and prostate tissue, although the lesion has been undetectable with ultrasound. The imaging results have been compared with visual examination of surgically excised prostates. Although axial resolution of the wide-band transducers employed in the transrectal probe provides good axial resolution of 0.5 mm, the convex arc geometry of the this array of transducers provides lateral resolution degrading with depth in tissue. A two step algorithm has been developed to improve the lateral resolution of deeply located objects. This algorithm employs optoacoustic image reconstruction based on radial back-projection to determine location and shape of the target object, then a procedure, we call Maximum Angular Amplitude Probability (MAAP), to determine true brightness of the object and simultaneously remove arc-shaped artifacts associated with radial back-projection. A laser optoacoustic imaging system (LOIS-P) with transrectal probe operating in backward detection mode empowered with the new image reconstruction algorithm seems promising as a modality for detection of prostate cancer and guiding prostate biopsy.
机译：我们已经开发并使用了带有经直肠探针（LOIS-P）的激光光声成像系统，用于在体内检测犬前列腺的机械损伤。 LOIS图像已使用128通道经直肠探头和32通道数据采集系统采集。与超声图像相比，光声图像对包含病变的血液显示出强烈的对比度增强。我们的研究表明，尽管超声无法检测到病变，但在包含病变的血液和前列腺组织之间存在足够的光声对比。成像结果已与目测检查切除的前列腺进行了比较。尽管经直肠探针中使用的宽带换能器的轴向分辨率提供了0.5 mm的良好轴向分辨率，但是此换能器阵列的凸弧几何形状提供了随组织深度而降低的横向分辨率。已经开发了一种两步算法来提高深处物体的横向分辨率。该算法采用基于径向反投影的光声图像重建来确定目标物体的位置和形状，然后使用称为最大角振幅概率（MAAP）的过程来确定物体的真实亮度并同时去除弧形伪像与径向背投影有关。具有向后探测模式的经直肠探针操作的激光光声成像系统（LOIS-P），借助新的图像重建算法，有望作为一种检测前列腺癌和指导前列腺活检的方法。

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