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首页> 外文会议>Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-Optics >In vivo testing of laser optoacoustic system for image-guided biopsy of prostate
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In vivo testing of laser optoacoustic system for image-guided biopsy of prostate

机译：激光光声系统的体内测试，用于预防型前列腺的图像引导活检

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We have developed and used a laser optoacoustic imaging system with transrectal probe (LOIS-P) for detection of mechanical lesions in canine prostates in vivo. LOIS images have been acquired with a 128-channel transrectal probe and a 32-channel data acquisition system. Optoacoustic images showed a strong contrast enhancement for a blood containing lesion, when compared with ultrasound images. Our studies demonstrated that sufficient optoacoustic contrast exists between blood containing lesion and prostate tissue, although the lesion has been undetectable with ultrasound. The imaging results have been compared with visual examination of surgically excised prostates. Although axial resolution of the wide-band transducers employed in the transrectal probe provides good axial resolution of 0.5 mm, the convex arc geometry of the this array of transducers provides lateral resolution degrading with depth in tissue. A two step algorithm has been developed to improve the lateral resolution of deeply located objects. This algorithm employs optoacoustic image reconstruction based on radial back-projection to determine location and shape of the target object, then a procedure, we call Maximum Angular Amplitude Probability (MAAP), to determine true brightness of the object and simultaneously remove arc-shaped artifacts associated with radial back-projection. A laser optoacoustic imaging system (LOIS-P) with transrectal probe operating in backward detection mode empowered with the new image reconstruction algorithm seems promising as a modality for detection of prostate cancer and guiding prostate biopsy.
机译：我们已经开发并使用了具有癌症探针（LOIS-P）的激光光声成像系统，用于检测体内犬类前列腺的机械病变。已经用128通道转基站探头和32通道数据采集系统获取了LOIS图像。与超声图像相比，光声图像显示出含有病变的血液的强烈对比增强。我们的研究表明，在含有病变和前列腺组织之间存在足够的光声对比，尽管损伤已经不可检测到超声波。已经将成像结果与手术切除前列腺的视觉检查进行了比较。尽管在跨型探针中采用的宽带换能器的轴向分辨率提供良好的轴向分辨率为0.5mm，但该换能器阵列的凸电弧几何形状提供横向分辨率，在组织中深度降低。已经开发了两个步骤算法以提高深度定位物体的横向分辨率。该算法采用基于径向背部投影的光声图像重建，以确定目标对象的位置和形状，然后是一个过程，我们呼叫最大角度幅度概率（MAAP），以确定对象的真正亮度，同时去除弧形伪像与径向后投影相关联。一种激光光声成像系统（LOIS-P）与经直肠探头在与所述新的图像重建算法授权向后检测模式操作似乎有希望作为用于检测前列腺癌的形态和引导前列腺活检。

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