...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery.
【24h】

Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery.

机译：基于生物等同剂考虑的多种等中心伽马刀放射前射击射击测序。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rapid delivery of multiple shots or isocenters is one of the hallmarks of Gamma Knife radiosurgery. In this study, we investigated whether the temporal order of shots delivered with Gamma Knife Perfexion would significantly influence the biological equivalent dose for complex multi-isocenter treatments. Twenty single-target cases were selected for analysis. For each case, 3D dose matrices of individual shots were extracted and single-fraction equivalent uniform dose (sEUD) values were determined for all possible shot delivery sequences, corresponding to different patterns of temporal dose delivery within the target. We found significant variations in the sEUD values among these sequences exceeding 15% for certain cases. However, the sequences for the actual treatment delivery were found to agree (<3%) and to correlate (R(2) = 0.98) excellently with the sequences yielding the maximum sEUD values for all studied cases. This result is applicable for both fast and slow growing tumors with alpha/beta values of 2 to 20 according to the linear-quadratic model. In conclusion, despite large potential variations in different shot sequences for multi-isocenter Gamma Knife treatments, current clinical delivery sequences exhibited consistent biological target dosing that approached that maximally achievable for all studied cases.
机译：快速交付多次射击或isocenters是伽马刀放射外科的标志之一。在这项研究中，我们研究了用伽马刀完美的拍摄的时间顺序是否会影响复杂的多等候化治疗的生物当量剂量。选择了二十个单一目标病例进行分析。对于每种情况，提取单个射击的3D剂量矩阵，针对所有可能的射击递送序列确定单级分数等效均匀剂量（Seud）值，对应于靶内的不同时间剂量递送的不同模式。对于某些情况，我们发现这些序列中的序列值的显着变化。然而，发现实际治疗递送的序列同意（<3％）并与所有研究病例的最大Seud值相关，并与所有研究的序列相同（R（2）= 0.98）。根据线性二次模型，该结果适用于快速和缓慢生长的肿瘤，α/β值2至20。总之，尽管不同射击序列的不同射击序列具有大的潜在变化，但目前的临床递送序列表现出一致的生物靶点给药，其接近所有研究的病例最大可达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号