...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physics in medicine and biology. >Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery.
【24h】

Shot sequencing based on biological equivalent dose considerations for multiple isocenter Gamma Knife radiosurgery.

机译：基于生物等效剂量考量的多次等中心伽玛刀放射外科手术的注射测序。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rapid delivery of multiple shots or isocenters is one of the hallmarks of Gamma Knife radiosurgery. In this study, we investigated whether the temporal order of shots delivered with Gamma Knife Perfexion would significantly influence the biological equivalent dose for complex multi-isocenter treatments. Twenty single-target cases were selected for analysis. For each case, 3D dose matrices of individual shots were extracted and single-fraction equivalent uniform dose (sEUD) values were determined for all possible shot delivery sequences, corresponding to different patterns of temporal dose delivery within the target. We found significant variations in the sEUD values among these sequences exceeding 15% for certain cases. However, the sequences for the actual treatment delivery were found to agree (<3%) and to correlate (R(2) = 0.98) excellently with the sequences yielding the maximum sEUD values for all studied cases. This result is applicable for both fast and slow growing tumors with alpha/beta values of 2 to 20 according to the linear-quadratic model. In conclusion, despite large potential variations in different shot sequences for multi-isocenter Gamma Knife treatments, current clinical delivery sequences exhibited consistent biological target dosing that approached that maximally achievable for all studied cases.
机译：快速发射多个镜头或等中心点是伽玛刀放射外科手术的标志之一。在这项研究中，我们调查了伽玛刀Perfexion注射的时间顺序是否会显着影响复杂的多等中心治疗的生物等效剂量。选择了20个单目标病例进行分析。对于每种情况，提取单个注射的3D剂量矩阵，并为所有可能的注射递送序列确定单分数等效均匀剂量（sEUD）值，对应于目标内时间剂量递送的不同模式。在某些情况下，我们发现这些序列中sEUD值的显着变化超过15％。但是，发现实际治疗的序列与所有研究病例中产生最大sEUD值的序列非常吻合（<3％），并且与相关性（R（2）= 0.98）非常相关。根据线性二次模型，该结果适用于α/β值为2至20的快速和缓慢生长的肿瘤。总之，尽管对于多等中心伽玛刀治疗，不同注射顺序可能存在很大差异，但当前的临床给药顺序仍显示出一致的生物学目标剂量，该剂量接近了所有研究病例均可达到的最大剂量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号