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首页> 外文期刊>Physics in medicine and biology. >Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins.
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Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins.

机译：分数次呼吸模式变异与个性化运动评估边距的放射疗法的额外后果。

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摘要

The data from eight patients who had undergone stereotactic body radiotherapy were selected due to their 4D-CT planning scans showing that their tumours had respiratory induced motion trajectories of large amplitude (greater than 9 mm in cranio-caudal direction). Radiotherapy plans with personalized motion-assessed margins were generated for these eight patients. The margins were generated by inverse 4D planning on an eight-bin phase-sorted 4D-CT scan. The planning was done on an in-house software system with a non-rigid registration stage being completed using freely available software. The resultant plans were then recalculated on a 4D-CT scan taken later during the course of treatment. Simulated image-guided patient set-up was used to align the geometric centres of the tumour region and minimize any misalignment between the two reconstructions. In general, the variation in the patient breathing patterns was found to be very small. Consequently, the degradation of the mean dose to the tumour region was found to be around a few percent (<3%) and hence was not a large effect.
机译：由于其4D-CT计划扫描，选择了一所经过立体定向体放射疗法的患者的数据，表明其肿瘤具有呼吸诱导的大振幅（颅尾方向大于9毫米）的呼吸诱导运动轨迹。为这八名患者产生了具有个性化运动评估边距的放射疗法计划。边缘由逆4D规划在八箱阶段排序的4D-CT扫描上产生。规划是在内部软件系统上完成的，使用自由可用的软件完成了非刚性注册阶段。然后在治疗过程中稍后在4D-CT扫描中重新计算所得计划。模拟图像引导患者设置用于对准肿瘤区域的几何中心，并最大限度地减少两个重建之间的任何未对准。通常，发现患者呼吸模式的变化非常小。因此，发现肿瘤区域的平均剂量的降解约为百分之大（<3％），因此不是很大的效果。

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