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首页> 外文期刊>Physics in medicine and biology. >Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins.
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Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins.

机译：分数间呼吸模式变化对放射治疗的剂量学后果，并带有个性化的运动评估边缘。

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摘要

The data from eight patients who had undergone stereotactic body radiotherapy were selected due to their 4D-CT planning scans showing that their tumours had respiratory induced motion trajectories of large amplitude (greater than 9 mm in cranio-caudal direction). Radiotherapy plans with personalized motion-assessed margins were generated for these eight patients. The margins were generated by inverse 4D planning on an eight-bin phase-sorted 4D-CT scan. The planning was done on an in-house software system with a non-rigid registration stage being completed using freely available software. The resultant plans were then recalculated on a 4D-CT scan taken later during the course of treatment. Simulated image-guided patient set-up was used to align the geometric centres of the tumour region and minimize any misalignment between the two reconstructions. In general, the variation in the patient breathing patterns was found to be very small. Consequently, the degradation of the mean dose to the tumour region was found to be around a few percent (<3%) and hence was not a large effect.
机译：由于他们的4D-CT计划扫描显示他们的肿瘤具有大幅度的呼吸诱发运动轨迹（在颅尾方向上大于9 mm），因此选择了八名接受了立体定向身体放疗的患者的数据。为这八名患者生成了带有个性化运动评估余量的放疗计划。边距是通过在八格相位分类的4D-CT扫描上进行逆4D计划生成的。该计划是在内部软件系统上完成的，使用可免费获得的软件完成了非刚性注册阶段。然后，在治疗过程中稍后进行的4D-CT扫描中重新计算最终计划。模拟的图像引导患者设置用于对齐肿瘤区域的几何中心，并最大程度地减少两次重建之间的任何未对齐。通常，发现患者呼吸模式的变化很小。因此，发现对肿瘤区域的平均剂量的降解约为百分之几（＜3％），因此效果不大。

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