T regulatory cells in contact hypersensitivity.

Cavani A

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T regulatory cells in contact hypersensitivity.

机译：T调节细胞接触超敏反应。

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PURPOSE OF REVIEW: The review summarizes the recent investigations focused on T regulatory cells in hapten diseases. RECENT FINDINGS: Multiple mechanisms ensure tolerance to small chemicals penetrating the skin. Among these, specific T regulatory cells play a major role in controlling harmful immune responses to environmental antigens. Most of the T regulatory cells involved in this process belongs to the CD4 subset and suppress hapten-specific immune response through the release of IL-10 and through direct interaction with effector T cells, blocking their function. SUMMARY: Methods for in-vitro and in-vivo expansion of specific T regulatory cells may represent an innovative approach for the cure of contact hypersensitivity.

机译：综述的目的：综述总结了针对半抗原疾病中T调节细胞的最新研究。最近的发现：多种机制确保了对渗透皮肤的小化学物质的耐受性。其中，特定的T调节细胞在控制对环境抗原的有害免疫反应中起主要作用。参与此过程的大多数T调节细胞都属于CD4子集，并通过释放IL-10和与效应T细胞直接相互作用来抑制半抗原特异性免疫反应，从而阻断其功能。摘要：用于体外和体内扩增特定T调节细胞的方法可能代表了一种治疗接触性超敏反应的创新方法。

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《Current opinion in allergy and clinical immunology》 |2008年第4期|共5页
作者
Cavani A;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
regulatory; Hypersensitivity; Contact; Haptens; 半抗原;

机译：regulatory;Hypersensitivity;Contact;Haptens;半抗原;

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专利

1. T regulatory cells in contact hypersensitivity. [J] . Cavani A Current opinion in allergy and clinical immunology . 2008,第4期

机译：T调节细胞接触超敏反应。
2. Negative regulatory effect of histamine in DNFB-induced contact hypersensitivity. [J] . Garaczi E, Szell M, Janossy T, International immunology. . 2004,第12期

机译：组胺对DNFB引起的接触性超敏反应的负调节作用。
3. IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. [J] . Nakae S, Naruse-Nakajima C, Sudo K, International immunology. . 2001,第12期

机译：在接触超敏反应的敏化阶段，接触性过敏原特异性T细胞活化需要IL-1 alpha，但不是IL-1 beta。
4. Controlled Release Systems to Increase Local Numbers of Regulatory T Cells Suppress Contact Hypersensitivity [C] . Stephen C. Balmert, Siddharth Jhunjhunwala, Giorgio Raimondi, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：控释系统可增加调节性T细胞的局部数量并抑制接触超敏反应
5. Neisseria gonorrhoeae regulatory networks involved in the response to host cell contact [D] . Du, Ying 2006

机译：淋病奈瑟氏球菌调控网络参与对宿主细胞接触的反应
6. Role of F4/80+ cells during induction of hapten-specific contact hypersensitivity. [O] . I Kurimoto, S F Grammer, T Shimizu, 1995

机译：F4 / 80 +细胞在诱导半抗原特异性接触超敏反应中的作用。
7. Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity. [O] . Atsushi Otsuka, Masato Kubo, Tetsuya Honda, 2011

机译：肥大细胞和皮肤树突细胞之间相互作用的要求，以建立接触性超敏反应。

T regulatory cells in contact hypersensitivity.

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