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首页> 外文期刊>Current opinion in anaesthesiology >The propofol infusion syndrome in infants and children: Can we predict the risk?
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The propofol infusion syndrome in infants and children: Can we predict the risk?

机译：婴幼儿异丙酚输注综合征：我们可以预测风险吗？

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Propofol has been an immensely successful anaesthetic induction agent but there is an increasing number of reports of serious complications when it has been used as an infusion to provide sedation for prolonged periods. The first reports involved children who died from intractable myocardial failure preceded by a metabolic acidosis, lipaemic plasma, fatty infiltration of the liver and evidence of muscle damage. As more cases have been reported the association between propofol and the syndrome has become more certain. Recently adult cases have appeared and a metabolic explanation has been suggested. The syndrome has a high mortality and the only effective treatment appears to be dialysis. < copyright > 2002 Lippincott Williams & Wilkins.
机译：异丙酚是一种非常成功的麻醉诱导剂，但是越来越多的报道称，当将丙泊酚用作输注剂以长时间提供镇静作用时，会出现严重的并发症。第一批报道涉及因难治性心肌衰竭而死亡的儿童，其后发生代谢性酸中毒，血脂血浆，肝脏脂肪浸润和肌肉损害的证据。随着更多病例的报道，丙泊酚与该综合征之间的关联变得更加确定。最近出现了成年病例，并提出了新陈代谢的解释。该综合征的死亡率很高，唯一有效的治疗方法似乎是透析。 <版权> 2002 Lippincott Williams＆Wilkins。

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