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Neuromuscular and mitochondrial disorders: what is relevant to the anaesthesiologist?

机译：神经肌肉和线粒体疾病：与麻醉医师有什么关系？

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PURPOSE OF REVIEW: The review provides an up-to-date information to the anaesthesiologist about the more frequent and important neuromuscular disorders for which new basic insights or clinical implications have been reported. RECENT FINDINGS: The findings include the mechanisms of the hyperkalemia after succinylcholine in patients with upregulation of acetylcholine receptors. New insights into the mechanism of malignant hyperthermia-like reactions such as rhabdomyolysis during anaesthesia in patients with Duchenne muscular dystrophy have been published. The importance of mitochondrial defects and the effect of agents used in anaesthesia on mitochondrial function are also highlighted. SUMMARY: The increased understanding of the genetics and pathophysiology of common muscle disorders may lead to a decrease in life-threatening complications related to surgery and anaesthesia. However, there is still a lack of prospective clinical studies to determine which is the safest anaesthetic technique for these patients.
机译：审查的目的：审查向麻醉师提供有关较频繁和重要的神经肌肉疾病的最新信息，这些疾病已报告了新的基本见解或临床意义。最近的发现：研究结果包括乙酰胆碱受体上调的患者在琥珀酰胆碱引起的高钾血症的机制。已经发表了有关杜兴氏肌肉营养不良患者麻醉期间发生横纹肌溶解等恶性高热样反应机制的新见解。还强调了线粒体缺陷的重要性以及麻醉剂对线粒体功能的影响。摘要：对常见肌肉疾病的遗传学和病理生理学的加深了解可能会减少与手术和麻醉有关的威胁生命的并发症。但是，仍然缺乏前瞻性的临床研究来确定对于这些患者来说最安全的麻醉技术。

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