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首页> 外文期刊>Current opinion in anaesthesiology >Protecting the kidney during critical illness.
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Protecting the kidney during critical illness.

机译：在重大疾病期间保护肾脏。

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PURPOSE OF REVIEW: Acute renal failure causes considerable morbidity and mortality in critically ill patients. To date, there are few therapies available to clinicians that alter outcome. This review will focus on clinical and basic science research efforts related to the diagnosis, pathophysiology, prevention, and treatment of acute renal failure. RECENT FINDINGS: The incidence of acute renal failure may be increasing and the mortality rate continues to be significant. The development of sensitive, predictive biomarkers of acute renal failure may help to diagnose the syndrome earlier and allow for meaningful therapeutic intervention. A number of new therapies are in development for acute renal failure. Many show promise in animal models of acute renal failure but prospective studies in humans are lacking. SUMMARY: Despite the present lack of therapies for the treatment and prevention of acute renal failure, there are reasons to be optimistic. Recent research has led to the development of several different strategies that may provide a breakthrough in the treatment of acute renal failure.
机译：审查目的：急性肾功能衰竭在危重患者中引起相当大的发病率和死亡率。迄今为止，很少有临床医生可以改变结果的疗法。这篇综述将侧重于与急性肾衰竭的诊断，病理生理，预防和治疗有关的临床和基础科学研究工作。最近的发现：急性肾衰竭的发生率可能正在增加，并且死亡率仍然很高。急性肾衰竭的敏感，可预测的生物标志物的发展可能有助于早期诊断该综合征，并进行有意义的治疗干预。针对急性肾衰竭的许多新疗法正在开发中。许多动物在急性肾衰竭的动物模型中显示出希望，但缺乏对人类的前瞻性研究。摘要：尽管目前缺乏用于治疗和预防急性肾衰竭的疗法，但仍有理由感到乐观。最近的研究导致了几种不同策略的发展，这些策略可能为急性肾衰竭的治疗提供突破。

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